Essentials

Question 1

Phenytoin: P450 inhibitor or inducer?

Answer 1

Inducer

Question 2

Allopurinol: P450 inhibitor or inducer?

Answer 2

Inhibitor

Question 3

Carbamazepine: P450 inhibitor or inducer?

Answer 3

Inducer

Question 4

Rifampicin: P450 inhibitor or inducer?

Answer 4

Inducer

Question 5

Erythromycin: P450 inhibitor or inducer?

Answer 5

Inhibitor

Question 6

Trimethoprim: P450 inhibitor or inducer?

Answer 6

Inhibitor

Question 7

Valproate: P450 inhibitor or inducer?

Answer 7

Inhibitor

Question 8

Alcohol: P450 inhibitor or inducer?

Answer 8

Acute: inhibitor, chronic excess: inducer

Question 9

Phenobarbital: P450 inhibitor or inducer?

Answer 9

Inducer

Question 10

Omeprazole: P450 inhibitor or inducer?

Answer 10

Inhibitor

Question 11

Disulfiram: P450 inhibitor or inducer?

Answer 11

Inhibitor

Question 12

Gliclazide: P450 inhibitor or inducer?

Answer 12

Inducer

Question 13

Isoniazid: P450 inhibitor or inducer?

Answer 13

Inhibitor

Question 14

How long before surgery should lithium be stopped?

Answer 14

Day before

Question 15

How long before surgery should the cOCP be stopped?

Answer 15

4 weeks

Question 16

How long before surgery should potassium-sparing diuretics be stopped?

Answer 16

The day of

Question 17

How long before surgery should ACE inhibitors be stopped?

Answer 17

The day of

Question 18

Name a drug cause of hypokalaemia

Answer 18

Thiazide diuretics, loop diuretics

Question 19

Name a drug cause of hyperkalaemia

Answer 19

ACE inhibitors, potassium-sparing diuretics

Question 20

Name a drug that reduces production of platelets

Answer 20

Penicillamine

Question 21

Name a drug that increases destruction of platelets

Answer 21

Heparin

Question 22

Describe the features of early lithium toxicity

Answer 22

Tremor

Question 23

Describe the features of intermediate lithium toxicity

Answer 23

Fatigue

Question 24

Describe the features of late lithium toxicity

Answer 24

Arrhythmias, seizures, diabetes insipidus, renal failure, coma

Question 25

Describe the features of digoxin toxicity

Answer 25

Confusion, nausea, visual halos, yellow-tinted vision, arrhythmias

Question 26

Describe the features of phenytoin toxicity

Answer 26

Gingival hypertrophy, ataxia. nystagmus, peripheral neuropathy

Question 27

Describe the features of gentamicin/vancomycin toxicity

Answer 27

Nephrotoxicity, ototoxicity

Question 28

Name 2 drug causes of neutropaenia

Answer 28

Clozapine, carbimazole

Question 29

Describe the difference between carbimazole and carbamazepine

Answer 29

Carbimazole: anti-thyroid Carbamazepine: anti-epileptic

Question 30

St John's Wort: P450 inhibitor or inducer?

Answer 30

Inducer

Question 31

Smoking: P450 inhibitor or inducer?

Answer 31

Inducer

Question 32

Ketoconazole and fluconazole: P450 inhibitors or inducers?

Answer 32

Inhibitors

Question 33

SSRIs: P450 inhibitors or inducers?

Answer 33

Inhibitors

Question 34

Ritonavir: P450 inhibitor or inducer?

Answer 34

Inhibitor

Question 35

Amiodarone: P450 inhibitor or inducer?

Answer 35

Inhibitor