ESRD with PD Flashcards
What is Continuous Ambulatory Peritoneal Dialysis (CAPD)?
Manual exchanges
Gravity infusion of dialysate into peritoneal cavity –> dwell –> drain
Repeated 4-5 times/day with typically longer dwells at night
What is Continuous Cyclic Peritoneal Dialysis (CCPD)?
Type of automated peritoneal dialysis
Machine assisted
Shorter dwell times, usually done at night
May include daytime manual dwells
Usually night exchanges with dry day
What is Tidal Peritoneal Dialysis (TPD)?
Type of automated peritoneal dialysis
Machine assisted
Optimize solute clearance by leaving portion of dialysis fluid in peritoneal cavity throughout dialysis session.
Primarily used with poor cath function, low drain alarms, and drain discomfort
High volumes can improve clearances but can be costly and inconvenient
What is cleared through diffusion in PD?
From blood to dialysate: uremic solutes, K+
From dialysate to blood: glucose, lactate or bicarb, calcium
Depends on concentration gradient and molecular weight of solute, membrane surface area, membrane resistance
What affects ultrafiltration in PD?
Concentration gradient for osmotic agent (dextrose, icodextrin, AA).
Peritoneal membrane surface area and characteristics (permeability).
Hydrostatic and oncotic pressure gradients
What are the characteristics of high transporters based on PET?
Rapid solute clearance
Poor UF
High risk of alb. loss
Preferred dialysis: nocturnal intermittent PD w/ dry day; CCPD and avoid long day dwells.
What are the characteristics of high-average transporters based on PET?
Good solute clearance
Good UF
High-average risk of alb. loss
Preferred dialysis: CCPD or CAPD standard dose
What are the characteristics of low-average transporters based on PET?
Adequate/slower solute clearance
Good UF
Low-avg. risk of alb. loss
Preferred dialysis: CCPD or CAPD standard dose
What are the characteristics of low transporters based on PET?
Slow/inadequate solute clearance
Excellent UF
Low risk of alb. loss
Preferred dialysis: CAPD or high-dose PD, avoid short dwells
What determines rate at which solutes are removed during PD?
Rate of equilibrium between dialysate and blood.
What are ways to improve adequacy in CAPD?
Increase exchange volume–may increase sense of fullness, cause back pain, abd. distension
Increase frequency or number of exchanges
Increase osmotic pressure of dialysis (ex: increase % of dextrose)–may damage peritoneum over time.
What are ways to improve adequacy in APD?
Add a daytime dwell to improve urea and creatinine clearance–long dwells may cause net fluid resorption
Increase dwell volumes on cycler
Increase time on cycler
Increase frequency of cycles to maximize concentration gradient
Increase osmotic strength of dialysate (ex: increase % dextrose)
What are the protein recommendations for PD?
1.0-1.2 g/kg BW
1.2-1.3 g/kg BW may be most optimal
What are the kcal recommendations for PD?
25-35 kcal/kg BW
Include kcal absorbed from dextrose in dialysate.
What is icodextrin?
High molecular weight, starch-based glucose polymer
Helps maintain osmotic gradient and minimize kcal load of PD.
Helps with glycemic control
Approx 25% (~150 kcal) absorbed in 8-hour dwell