Erythropoiesis Flashcards
main function of erythrocytes
To carry oxygen from the lung to the tissues where O2 is released
How do RBCs carry oxygen?
By the attachment of oxygen to the hemoglobin in RBCs
secondary functions of RBCs
- return CO2 to lungs
- buffer the pH of blood
circular, homogenous discs of nearly uniform size ranging from 6-8 µm in diameter
RBCs
the process of RBC production
Erythropoiesis
Where does erythropoiesis occur?
In the bone marrow
islands on a bone marrow where macrophages are surrounded by erythroid precursors in various stages of development
Erythroid islands
Where does erythropoiesis originate from?
Pluripotent stem cells
the formation of all blood cellular components which include RBC
Hematopoiesis
Where does hematopoiesis originate from?
Hematopoietic stem cells (HSC)
HSC can self-renew and differentiate into ______
Committed hematopoietic progenitors
differentiation from HSC that cannot self-renew but can generate lineage committed progenitors
Multipotent progenitors (MPP)
earliest identifiable colony of RBCs
Burst-forming unit erythroid (BFUE)
trace the lineage of erythrocytes from the HSC
- HSC
- pluripotent hematopoietic stem cell
- common myeloid progenitor
- megakaryocyte-erythrocyte progenitor
- pronormoblast
- erythrocyte
BFUE will develop into colony forming unit erythroid (CFUE) under the influence of ________
- interleukin-3 (IL-3)
- granulocyte-monocyte colony stimulating factor (GM-CSF)
- thrombopoietin
- KIT ligand
