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Hematology Lec > Erythrocyte Production > Flashcards

Erythrocyte Production Flashcards

1
Q

Basophilia

A

Acidic components that attract basic stain (methylene blue)

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2
Q

Acidophilia

A

Basic components that attract acid stain

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3
Q

Characteristics of mature cell

A
  • N:C ratio decreases
  • Cell diameter decreases
  • cytoplasm change from blue to pink
  • Nuclear chromatin becomes condenser, coarser, and clumped
  • Nucleoli disappear
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4
Q

How many days to produce an RBC from simulation of the earliest erythroid progenitor to release in Bone marrow?

A

18-21 days

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5
Q

How long does it take for the first identifiable RBC precursor to mature and be released
into the circulation?

A

6-7 days

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6
Q

N:C ratio

A

visual estimate of nucleus and cytoplasm

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7
Q

Normoblastic Nomenclature

A
  • Pronormonoblast
  • Basophilic normoblast
  • Polychromatophilic/ matic normoblast
  • Orthochromatic normoblast
  • Polychromatophilic erythrocyte
  • Mature erythrocyte
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8
Q

Rubriblastic nomenclature

A
  • Rubriblast
  • Prorubicyte
  • Rubricyte
  • Metarubricyte
  • Polychromatophilic erythrocyte
  • Mature erythrocyte
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9
Q

Erythroblastic nomenclature

A
  • Proerythroblast
  • Basophilic erythroblast
  • Polychromatophilic/ matic erythroblast
  • Orthochromatic erythroblast
  • Polychromatophilic erythrocyte
  • Mature erythrocyte
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10
Q

1-2 Nucleoli

A

-Proerythroblast/Rubriblast/Pronormonoblast

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11
Q

No Nucleus and the last stage to synthesize hemoglobin

A

Polychromatophilic erythrocyte/ Reticulocyte

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12
Q

Last stage undergoes mitosis

A

Polychromatophilic/ matic erythroblast/Rubricyte/Polychromatophilic/ matic normoblast

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13
Q

Located at peripheral blood

A

Mature erythrocyte

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14
Q

Howell jelly bodies are found

A

Orthochromatic erythroblast/Metarubricyte/Orthochromatic normoblast

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15
Q

RBC mass

A

refers only to cells in circulation

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16
Q

Erythropoietin functions

A
  • Inhibit apoptosis
  • Early release of reticulocytes
  • Evasion of apoptosis by erythroid progenitors and precursors
17
Q

Erythron

A

collection of all stages of erythrocytes

18
Q

RBC life span

A

120 days

19
Q

What is senescence

A

old age or cellular aging

20
Q

other stimuli to erythropoiesis

A

thyroid hormones
pituitary hormones
testosterone

21
Q

CFU-E stands for

A

Colony Forming Unity-Erythroid

22
Q

Cause mechanical or traumatic stress

A

rupture of cell membrane while in circulation

23
Q

Death receptor

A

Fas

24
Q

Present on mature cell

A

FasL

25
Q

Stage where no nucleoli is present

A

Polychromatophilic/ matic erythroblast/Rubricyte/Polychromatophilic/ matic normoblast

Hematology Lec (3 decks)

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