Erythrocyte Production Flashcards
Basophilia
Acidic components that attract basic stain (methylene blue)
Acidophilia
Basic components that attract acid stain
Characteristics of mature cell
- N:C ratio decreases
- Cell diameter decreases
- cytoplasm change from blue to pink
- Nuclear chromatin becomes condenser, coarser, and clumped
- Nucleoli disappear
How many days to produce an RBC from simulation of the earliest erythroid progenitor to release in Bone marrow?
18-21 days
How long does it take for the first identifiable RBC precursor to mature and be released
into the circulation?
6-7 days
N:C ratio
visual estimate of nucleus and cytoplasm
Normoblastic Nomenclature
- Pronormonoblast
- Basophilic normoblast
- Polychromatophilic/ matic normoblast
- Orthochromatic normoblast
- Polychromatophilic erythrocyte
- Mature erythrocyte
Rubriblastic nomenclature
- Rubriblast
- Prorubicyte
- Rubricyte
- Metarubricyte
- Polychromatophilic erythrocyte
- Mature erythrocyte
Erythroblastic nomenclature
- Proerythroblast
- Basophilic erythroblast
- Polychromatophilic/ matic erythroblast
- Orthochromatic erythroblast
- Polychromatophilic erythrocyte
- Mature erythrocyte
1-2 Nucleoli
-Proerythroblast/Rubriblast/Pronormonoblast
No Nucleus and the last stage to synthesize hemoglobin
Polychromatophilic erythrocyte/ Reticulocyte
Last stage undergoes mitosis
Polychromatophilic/ matic erythroblast/Rubricyte/Polychromatophilic/ matic normoblast
Located at peripheral blood
Mature erythrocyte
Howell jelly bodies are found
Orthochromatic erythroblast/Metarubricyte/Orthochromatic normoblast
RBC mass
refers only to cells in circulation
Erythropoietin functions
- Inhibit apoptosis
- Early release of reticulocytes
- Evasion of apoptosis by erythroid progenitors and precursors
Erythron
collection of all stages of erythrocytes
RBC life span
120 days
What is senescence
old age or cellular aging
other stimuli to erythropoiesis
thyroid hormones
pituitary hormones
testosterone
CFU-E stands for
Colony Forming Unity-Erythroid
Cause mechanical or traumatic stress
rupture of cell membrane while in circulation
Death receptor
Fas
Present on mature cell
FasL
