Erythrocyte disorders

Question 1

Describe the hypochromia

Answer 1

Pale cells

MCH 30 g/dL

Question 2

What are the associated medical conditions of hypochromia?

Answer 2

Anemias:
Severe Fe defic
Sideroblastic
Thalassemia
Lead poisoning
Transferrin deficiency

Question 3

Describe target cells

Answer 3

Cells with dark center & periphery

Question 4

What are the associated medical conditions of target cells?

Answer 4

Liver disease
Thalassemia
Fe defic anemia
Hemoglobinopathy

Question 5

Define reticulocyte

Answer 5

a measurement and percentage of how many reticulocytes are in the blood

Question 6

Describe cigar cells

Answer 6

Cigar shaped cells

Question 7

What type of cells are associated with Iron deficiency anemia

Answer 7

Cigar cells

Question 8

What type of cells are characterized by large oval cells >9

Answer 8

Megalocytes

Question 9

What type of disorders are associated with Megalocytes?

Answer 9

• Megaloblastic anemia
• Pernicious anemia
• Chemotherapy

Question 10

Define Anisocytosis

Answer 10

Abnormal variation in size of cells

Question 11

What medical conditions are associated with anisocytosis?

Answer 11

Severe anemia
Fe defic anemia
Hemolytic anemia

Question 12

Define Poikilocytosis

Answer 12

Abnormal variation in shapes of cells

Question 13

What disorder of cells is Severe anemia associated with?

Answer 13

Poikilocytosis

Question 14

Describe Howell-Jolly Body cells

Answer 14

Spherical purple bodies within cells

Question 15

What medical conditions are associated with Howell-Jolly body cells?

Answer 15

Hyposplenism
Pernicious anemia (B12 def.) 
Thalassemia
Sickle cell
Hemolytic anemia

Question 16

Describe spherocyte cells

Answer 16

Spherical cells
Lack central palor
Small, dense
Loss of cell water

Question 17

What medical condition are spherocytes associated with?

Answer 17

spherocytosis

Question 18

Describe tear drop cells

Answer 18

Dacrocytes

Tear drop shaped

Question 19

What medical condition are associated with tear drop cells?

Answer 19

Myeloproliferative dz
Thalassemia
Pernicious anemia
Tuberculosis

Question 20

What is the cause of tear drop cells?

Answer 20

Compromised bone marrow space

Question 21

Describe elliptocytes

Answer 21

Oval-elongated cells

Question 22

What medical condition is associated with elliptocytes?

Answer 22

Fe defic anemia

Question 23

What medical conditions are associated with nucleated RBC?

Answer 23

Hemolytic anemia
Polycythema vera
Severe anemia
Multiple myeloma

Question 24

What type of cell has a characteristic RBC with nucleus still present?

Answer 24

Nucleated RBC

Question 25

Describe schistocyte cells

Answer 25

Fragmentation of RBCs | Helmet cells

Question 26

What medical conditions are associated with schistocytes?

Answer 26

``` Severe burns Lead poisoning Snake bites Vasculitis Thrombocytopenia ```

Question 27

What type of cells are crescent shaped

Answer 27

Sickle cells

Question 28

What disease is associated with sickle cells?

Answer 28

Sickle cell disease

Question 29

What type of cells are characterized by Clumping of RBCs in disorganized mass

Answer 29

Agglutination

Question 30

What disease is agglutination associated with?

Answer 30

Cold agglutinin disease

Question 31

What type of cells present with a stack of coins formation?

Answer 31

Rouleaux

Question 32

What type of medical condition is associated with Rouleax?

Answer 32

proteinopathy

Question 33

What type of cells are characterized by Dust-like iron granules within cell?

Answer 33

Siderocytes

Question 34

What type of diseases are associated with sideocytes?

Answer 34

Sideroblastic anemia Hyposplenism Hemochromatosis

Question 35

What are the medical conditions CVD, Cirrhosis, Neoplasm associated with?

Answer 35

Stomatocytes

Question 36

Describe stomatocytes

Answer 36

Loss of red cell membrane | Ring of Pallor within cell

Question 37

Describe what acanthocytes look like

Answer 37

Spiculated-spur shape | Thorny projections

Question 38

What medical conditions are associated with acanthocytes?

Answer 38

Alcoholic Cirrhosis Pancreatitis Hemolytic anemia Malabsortion

Question 39

What is the cause of acanthocyte cells?

Answer 39

Accumulation of cholesterol in cell membrane

Question 40

Define Porphyria

Answer 40

- Group of diseases caused by a deficit in enzymes involved in porphyrin metabolism - Inherited defects in heme biosynthesis that result in excess production of prophyrin precursors

Question 41

What test do you use for Erythrocyte Porphorins?

Answer 41

Standard RBC protporphyrin assay | -Used to differentiate between porphyrias

Question 42

Describe the characteristics of Burr cells?

Answer 42

Echinocytes Burr-like cells Rounded spinous projections

Question 43

What medical conditions are associated with Burr cells

Answer 43

Artifact ( EDTA) Stomach Cancer Uremia

Question 44

* Go back for objectives 2, 3, and 4

Answer 44

ESR and porphyrias