Erythrocyte disorders Flashcards

1
Q

Describe the hypochromia

A

Pale cells

MCH 30 g/dL

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2
Q

What are the associated medical conditions of hypochromia?

A
Anemias:
Severe Fe defic
Sideroblastic
Thalassemia
Lead poisoning
Transferrin deficiency
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3
Q

Describe target cells

A

Cells with dark center & periphery

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4
Q

What are the associated medical conditions of target cells?

A

Liver disease
Thalassemia
Fe defic anemia
Hemoglobinopathy

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5
Q

Define reticulocyte

A

a measurement and percentage of how many reticulocytes are in the blood

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6
Q

Describe cigar cells

A

Cigar shaped cells

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7
Q

What type of cells are associated with Iron deficiency anemia

A

Cigar cells

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8
Q

What type of cells are characterized by large oval cells >9

A

Megalocytes

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9
Q

What type of disorders are associated with Megalocytes?

A
  • Megaloblastic anemia
  • Pernicious anemia
  • Chemotherapy
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10
Q

Define Anisocytosis

A

Abnormal variation in size of cells

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11
Q

What medical conditions are associated with anisocytosis?

A

Severe anemia
Fe defic anemia
Hemolytic anemia

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12
Q

Define Poikilocytosis

A

Abnormal variation in shapes of cells

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13
Q

What disorder of cells is Severe anemia associated with?

A

Poikilocytosis

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14
Q

Describe Howell-Jolly Body cells

A

Spherical purple bodies within cells

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15
Q

What medical conditions are associated with Howell-Jolly body cells?

A
Hyposplenism
Pernicious anemia (B12 def.) 
Thalassemia
Sickle cell
Hemolytic anemia
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16
Q

Describe spherocyte cells

A

Spherical cells
Lack central palor
Small, dense
Loss of cell water

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17
Q

What medical condition are spherocytes associated with?

A

spherocytosis

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18
Q

Describe tear drop cells

A

Dacrocytes

Tear drop shaped

19
Q

What medical condition are associated with tear drop cells?

A

Myeloproliferative dz
Thalassemia
Pernicious anemia
Tuberculosis

20
Q

What is the cause of tear drop cells?

A

Compromised bone marrow space

21
Q

Describe elliptocytes

A

Oval-elongated cells

22
Q

What medical condition is associated with elliptocytes?

A

Fe defic anemia

23
Q

What medical conditions are associated with nucleated RBC?

A

Hemolytic anemia
Polycythema vera
Severe anemia
Multiple myeloma

24
Q

What type of cell has a characteristic RBC with nucleus still present?

A

Nucleated RBC

25
Q

Describe schistocyte cells

A

Fragmentation of RBCs

Helmet cells

26
Q

What medical conditions are associated with schistocytes?

A
Severe burns
Lead poisoning
Snake bites
Vasculitis
Thrombocytopenia
27
Q

What type of cells are crescent shaped

A

Sickle cells

28
Q

What disease is associated with sickle cells?

A

Sickle cell disease

29
Q

What type of cells are characterized by Clumping of RBCs in disorganized mass

A

Agglutination

30
Q

What disease is agglutination associated with?

A

Cold agglutinin disease

31
Q

What type of cells present with a stack of coins formation?

A

Rouleaux

32
Q

What type of medical condition is associated with Rouleax?

A

proteinopathy

33
Q

What type of cells are characterized by Dust-like iron granules within cell?

A

Siderocytes

34
Q

What type of diseases are associated with sideocytes?

A

Sideroblastic anemia
Hyposplenism
Hemochromatosis

35
Q

What are the medical conditions CVD, Cirrhosis, Neoplasm associated with?

A

Stomatocytes

36
Q

Describe stomatocytes

A

Loss of red cell membrane

Ring of Pallor within cell

37
Q

Describe what acanthocytes look like

A

Spiculated-spur shape

Thorny projections

38
Q

What medical conditions are associated with acanthocytes?

A

Alcoholic Cirrhosis
Pancreatitis
Hemolytic anemia
Malabsortion

39
Q

What is the cause of acanthocyte cells?

A

Accumulation of cholesterol in cell membrane

40
Q

Define Porphyria

A
  • Group of diseases caused by a deficit in enzymes involved in porphyrin metabolism
  • Inherited defects in heme biosynthesis that result in excess production of prophyrin precursors
41
Q

What test do you use for Erythrocyte Porphorins?

A

Standard RBC protporphyrin assay

-Used to differentiate between porphyrias

42
Q

Describe the characteristics of Burr cells?

A

Echinocytes
Burr-like cells
Rounded spinous projections

43
Q

What medical conditions are associated with Burr cells

A

Artifact ( EDTA)
Stomach Cancer
Uremia

44
Q
  • Go back for objectives 2, 3, and 4
A

ESR and porphyrias