Anemia Flashcards
Define reticulocyte count
Ability of bone marrow to produce mature red blood cells
What is the difference between the increased and decreased reticulocyte count?
-Increased Retic Count (> 2%)
Bone marrow is adequately responding to anemia
Blood loss, hemolysis, response to therapy
-Decreased Retic Count (< 2%)
Inability of bone marrow to compensate for anemia
Normocytic, Microcytic, Macrocytic anemias
Define Mean Corpuscular Volume (MCV)
Volume or size of ave RBC
Classifies anemia
Define red blood cell count
of RBCs
Define hemoglobin
concentration of hemoglobin in whole blood
Define hematocrit
% of whole blood comprised of RBCs
Define mean corpuscular hemoglobin (MCH)
Weight of hemoglobin in ave RBC
Diagnosis of severe anemia
Define mean corpuscular hemoglobin concentration (MCHC)
Amount of hemoglobin present in ave RBC when compared to it’s size
Monitors therapy for anemia
Define red cell distribution width (RDW)
Measure of variability in RBC size
What diseases/conditions are associated with increased RBC count?
Polycythemia vera Renal disease Pulmonary disease CV disease High altitude Erythrocytosis
What diseases/conditions are associated with decreased RBC count?
Anemia Hodgkin’s disease Multiple myeloma Hemorrhage SLE Rheumatoid arthritis
What conditions are associated with increased HCT?
Erythrocytosis
Polycythemia vera
Shock
What conditions are associated with decreased HCT and Hb?
Cancer
Chronic disease
Blood loss
Hemolytic anemia
What conditions are associated with increased hemoglobin?
Polycythemia vera
CHF
COPD
What condition is associated with an increase or decrease in iron?
necessary for production of Hb
What condition is associated with an increase or decrease in ferritin?
Reflects body iron stores
What condition is associated with an increase or decrease in ferritin?
Transport protein synthesized by liver
Regulates iron absortion
What condition is associated with an increase or decrease in total iron binding capacity (TIBC)?
Iron binding capacity of RBC
What condition is associated with an increase or decrease in Vitamin B12?
Necessary for production of RBCs
What condition is associated with an increase or decrease in Folate-Vitamin B9?
neural tube development
What test, examines for pernicious anemia?
B12
What is the most common type of Anemia?
Iron deficient anemia
What is the most common cause of macrocytic anemia?
Vitamin B12 deficiency
What are the most common causes of Normocytic anemia?
Hemolytic, Aplastic
also decreased erythropoietin
