ER, Golgi, & Protein Processing

Question 1

Which one of the following processes takes place in the smooth endoplasmic reticulum?
A. folding of proteins
B. glucose-6-phosphatase reaction
C. glucose-6-phosphate dehydrogenase reaction
D. Oligosaccharyl transferase reaction
E. Proteolytic cleavage of propproteins

Answer 1

B. glucose-6-phosphatase reaction

Question 2

Secretion of protein by a cell is an example of
A. anterograde transport
B. cisternal maturation
C. endocytosis
D. proof-reading for protein synthesis
E. retrograde transport

Answer 2

A. anterograde transport

Question 3

On which amino acid residue is protein N-glycosylation most likely to occur?
A. Arginine
B. Asparagine
C. Aspartic acid
D. Serine
E. Threonine

Answer 3

B. Asparagine

Question 4

On which amino acid residue is protein O-glycosylation most likely to occur? LDL receptor
A. Arginine
B. Asparagine
C. Glutamine
D. Threonine
E. Tyrosine

Answer 4

D. Threonine

Question 5

Which one of the following is required for targeting a protein to be transported across the nuclear envelope?
A. Addition of mannose-6-phosphate
B. Cytoplasmic cleavage of a signal sequence
C. Disulfide bond formation
D. Glycosylation of the carboxy terminal
E. Intrinsic nuclear localization signal sequence

Answer 5

E. Intrinsic nuclear localization signal sequence

Question 6

Which one of the following monosaccharide is usually the last to be added during the glycosylation process?
A. Galactose
B. Glucose
C. Mannose
D. N-acetylglucosamine
E. Sialic acid

Answer 6

B. Glucose

Question 7

Which one of the following protein trafficking pathways does not require vesicular transport
A. Endocytosis
B. Lysosomal import
C. Mitochondrial import
D. Retrograde Transport
E. Secretion into extracellular space

Answer 7

C. Mitochondrial import