Equations PK/PD Flashcards
1
Q
Dose adjustment in renal failure - give dose, % renal function and Fu
A
Renal adj dose = Fc+ (Fu x dose x %renal adjustment)
Where Fc = (1 - Fu)
and renal adjustment is 25% of normal or CrCl of 90
2
Q
Loading dose =
A
Vd x [target plasma drug conc]
3
Q
Clearance = (given half life and Vd)
A
Vd x 0.7 / t1/2
4
Q
Half life =
(give clearance and Vd)
A
0.7 x Vd / Cl
5
Q
Maintenance dose =
A
Cl x [steady state conc]
6
Q
Renal clearance =
A
= Secreted clearance x Fu (fraction renally excreted) x GFR
