Cyp interactions Flashcards
1
Q
1A2
A
Inhibitors = Abx (erythromycin, ciprofloxacin) Substrates = clozapine, olanzepine
2
Q
2C9
A
Inhibitors: FluConazole
Substrate: Warfarin, Phenytoin, (NSAIDs)
3
Q
2C19
A
Inhibitors: PPI, Isoniazid
- Note will decrease effect of Clopidogrel as prodrug
Substrate: Clopidogrel **
Diazepam
4
Q
2D6
A
Inhibitors: Depression - SSRIs
Substrates: coDeine , D= Tamoxifen*, Metoprolol
5
Q
3A4
A
ABx - fungals (azole), macrolides (erythomycin), HIV - ritonavir
Substrate: CNI, amiodarone, verapamil, midazolam, statins, sildafenil, oesetrogens
6
Q
Always inducing (decrease effect of substrate unless prodrug)
A
CBZ
Phenytoin
Rifampicin
(St Johns Wort)