Equations

Question 1

Therapeutic Index

Answer 1

LD50/ED50

Question 2

Margin of Safety Index

Answer 2

LD1/ED99

Question 3

Protective Index

Answer 3

ED50 (undes)/ED50 (desirable)

Question 4

Kel: formula

Answer 4

Kel = 0.693/t1/2

Question 5

Co: what does it mean?

Answer 5

initial plasma concentration. meas immediately after a single dose has equilibrated between plasma and surrounding tissues

Question 6

Vd: what does it mean?

Answer 6

volume of distribution, apparent volume in which a drug is distributed.

Question 7

Vd: formula

Answer 7

Vd = D/Co

Question 8

D: meaning?

Answer 8

single dose

Question 9

Clp: meaning?

Answer 9

volume of plasma cleared of drug per unit tiem

Question 10

Clp: formula

Answer 10

Clp = Kel x Vd

Question 11

MD: meaning?

Answer 11

maintenance dose, dose required to achieve a steady state concentration

Question 12

Css: meaning?

Answer 12

steady state concentration

Question 13

MD: formula

Answer 13

MD = Css x Vd x Kel x dosing interval

Question 14

what if you are giving a constant IV dose: what happens to the MD formula?

Answer 14

ignore the dosing-interval and use MD = Css x Vd x Kel

Question 15

Loading dose: meaning?

Answer 15

dose rquired to instantly achieve a steady state concentration

Question 16

Loading dose: formula

Answer 16

D* = Css x Vd

Question 17

Foral: meaning?

Answer 17

total amount of drug that enters system from oral administration.

Question 18

Foral: formula

Answer 18

Foral = AUC oral / AUC iv

Question 19

what does a higher Foral indicate?

Answer 19

higher bioavailability

Question 20

Anther formula for MD using Vd x Kel = Clp

Answer 20

MD = Css x Clp x dosing interval