Epo PK/PD

Question 1

Erythropoietin is produced where?

Answer 1

THE KIDNEYS

Question 2

Erythropoietin is responsible for what?

Answer 2

RBC production

Question 3

Epo indications

Answer 3

CRF, cancer, AIDS, prematurity, autologous transfusion

Question 4

Epo ADEs

Answer 4

HTN, iron deficiency, pure red cell aplasia, increased survival of cancer cells

Question 5

Preferred route of administration of Epo

Answer 5

SQ

Question 6

Epo elimination is what?

Answer 6

Saturable elimination

Question 7

Tmax of Epo

Answer 7

5-30 hours

Question 8

Dual pathway of Epo absorption

Answer 8

Slow via the lymphatic system, fast via direct transport to the extravascular compartment

Question 9

Epo has what kind of kinetics?

Answer 9

FLIP-FLOP KINETICS

Question 10

Half life of Epo

Answer 10

24-79 hours

Question 11

Bioavailability of Epo

Answer 11

Dose-dependent

Question 12

Distribution of Epo

Answer 12

Central Vd is similar to plasma volume

Question 13

Elimination of Epo

Answer 13

Kidneys, liver, lymph all exert negligible effect on Epo CL

Question 14

Elimination pathways of Epo

Answer 14

EPOR-mediated endocytosis

EPOR-independent linear CL

Question 15

Does Epo follow TMDD?

Answer 15

Yes

Question 16

Markers of therapeutic response

Answer 16

Hematocrit, Hgb, RBC count, reticulocyte count

Question 17

Parameter for anemia classification and efficacy

Answer 17

Hemoglobin

Question 18

Normal range for Hgb

Answer 18

12-16 (anemia <8)

Question 19

Epo and gender

Answer 19

Difference between the PKPD in males and females but there’s no clinical significance to the difference

Question 20

Major factor contributing to the clinical efficacy of EPO

Answer 20

Clearance