Epithelium Flashcards
FOM 1, Exam 1, Lecture 7
What are the three functions of epithelium?
chemical exchange
homeostasis
absorption/secretion
Where is endothelium found?
blood vessels and lymph vessels
Where is mesothelium found?
peritoneal (abdominal wall) and serous cavities
What is the intraperitoneal layer called?
serosa
What is the retroperitoneal layer called?
adventitia
Where is myoepithelium found?
muscle and glands
Where is neuroepithelium found?
taste buds (sensory information)
Where is simple squamous epithelium found?
blood vessels
body cavities
parietal layer of renal corpuscles
Where is simple cuboidal epithelium found?
kidney tubules
small ducts of glands
free surface of ovary
Where is simple columnar epithelium found?
GI tract
uterus
large ducts of some glands
Where is stratified squamous epithelium found?
skin (keratinized) mucous membranes (non-keratinized)
Where is stratified cuboidal epithelium found?
larger ducts of sweat glands
Where is stratified columnar epithelium found?
larger ducts of mammary glands, salivary glands, and exocrine glands
Where is transition epithelium found?
urinary passages
Where is pseudostratified columnar epithelium found?
respiratory tract
epididymis
What are the four apical specializations of epithelium?
microvilli
stereocilia
cilia
flagella
What are microvilli comprised of?
folds of cell membranes
What are sterocilia comprised of?
bunches of actin filaments
What are cilia comprised of?
hair-like structures
Where is flagella found?
sperm
Where is microvilli found?
small intestine
proximal renal tubule
Where is stereocilia found?
Organ of Corti (ear)
epididymis
Which apical specializations are non-motile?
microvilli
stereocilia
Which apical specializations are motile?
cilia
flagella
What is the purpose of microvilli?
increase surface area for absorption
What is the purpose of stereocilia in the ear?
hearing/balance
What is the purpose of stereocilia in the epididymis?
absorption
What is the purpose of cilia and flagella?
propulsion
What is the core of microvilli?
actin
What is the function of spectrin?
stabilize the actin filaments to anchor them to the cytoplasm
What is the core of cilia?
9 + 2 microtubules
What are the microtubules in cilia anchored to?
basal bodies
How are the microtubules in cilia connected to one another in a circle?
nexin connects the radial tubules
What is the function of dynein in cilia?
hydrolyze ATP and slide to cause movement
What are the four lateral zones of epithelium?
zonula occludens
zonula adherens
macula adherens
gap junctions
What is the zonula occludens also known as?
tight junctions
What is the zonula adherens also known as?
anchoring junctions
What is the macula adherens also known as?
desmosomes
What does the zonula occludens aggregate with?
actin filaments
What does the zonula adherens aggregate with?
actin filaments
What does the macula adherens aggregate with?
intermediate filaments
What do gap junctions aggregate with?
protein channels
What enzyme seals off the intercellular space in tight junctions?
occludins
What enzyme seals off the intercellular space in anchoring junctions?
cadherins
How do anchoring junctions anchor the actin filaments?
actin filaments insert into plaques
What enzyme spot welds the intercellular space in desmosomes?
desmogleins
desmocollin
What are hemidesmosomes?
anchors cell to basal lamina
What are the two layers of the basal lamina?
lamina lucida
lamina dense
What type of collagen is found in the basal lamina?
type 4 collagen
What type of collagen is found in the reticular lamina?
type 3 collagen (reticular fibers)
What are the two types of exocrine gland?
unicellular and multicellular
What is the difference between the secretory process for unicellular and multicellular glands?
unicellular glands secrete directly into the lumen
multicellular gland secretions are carried by ducts
What are the most common type of unicellular gland?
Goblet cells
What are the two types of secretory products for exocrine glands?
mucous
serous
What is the consistency of mucous vs serous secretions?
thick vs watery
What is the primary molecule of mucous vs serous secretions?
glycoproteins (mucins) vs enzymes (zymogen granules)
Which has stronger cytoplasmic staining: mucous or serous glands)
serous because the basal cytoplasm is basophilic
Where are the nuclei located in mucous gland cells?
peripherally
Where are the nuclei located in serous gland cells?
centrally
What are the three modes of secretion?
merocrine/eccrine
apocrine
holocrine
What is the most common mode of secretion?
merocrine
How do merocrine glands work?
they secrete from the cell
Where are merocrine glands most commonly found?
pancreas
pituitary gland
eccrine sweat gland
How do apocrine glands work?
secrete through vesicles
Where are apocrine glands most commonly found?
mammary glands
apocrine sweat glands
How do holocrine glands work?
destroys the cell to release the contents
Where are holocrine glands most commonly found?
sebaceous glands of the skin
What are intercalated ducts?
small ducts that drain individual secretory units
What are striated ducts?
larger intercalated ducts that have basal infolding to concentrate secretions