Epinephrine

Question 1

Epinephrine; Class

Answer 1

Sympathominetic

Question 2

Epinephrine; Mechanism of Action

Answer 2

Direct acting Alpha and beta Agonist
Alpha:Bronchial, cutaneous, renal and visceral arteriolar Vasoconstriction
Beta 1: Positive inotropic and chronotropic actions
Beta 2: bronchial smooth muscle relaxation and dilations of skeletal vasculature
Blocks Histamine release

Question 3

Epinephrine; Indications

Answer 3

Cardiac arrest, Asystole, PEA, VF unresponsive to initial Defib. Severe bronchospasm, asthma, Bronchiolitis.
Anaphylaxis, acute allergic Rxn

Question 4

Epinephrine; Dosage and administration

Answer 4

Adult:
Allergic RXN/Asthma:0.3-0.5mg (0.3-0.5ml 1:1000) IM
Anaphylaxis: 0.3-0.5mg (3-5ml 1:10,000) IV
Cardiac:1mg IV push(1:10,000) every 3-5 min
Epi-Infusion: 1-10mcg/min
Pedi:
Allergic RXN/Asthma: 0.01mg/kg (0.01ml/kg 1:1000) IM max 0.5mg
Cardiac: Initial dose 0.01mg/kg (1:10,000 0.1ml/kg) IV,IO
Epi-infusion: 0.1-1mcg/kg/min IV,Im