EPINEPHRINE

Question 1

Epinephrine

Amount Carried

Answer 1

1: 1000 2 mg
1: 10,000 5 mg

Optional 30 mg mdv (1)

Question 2

Epninephrine

Concentration

Answer 2

(2) 1 mg/1 mL
(5) 1 mg/10 mL syringe

30 mg/30 mL vial

Question 3

Epinephrine

Indications

Answer 3

Cardiac arrest;

Severe bronchospasm;

Anaphylaxis;

Bradycardia;

Refractory hypotension;

Croup

Question 4

Epinephrine

Class

Answer 4

Natural catecholamine;

sympathomimetic

Question 5

Epinephrine

Mechanism of Action

Answer 5

Stimulates alpha, beta 1, and beta 2 receptor sites

Question 6

Epinephrine

Effects

Answer 6

alpha– vasoconstriction –> increase BP

beta 1– increase HR, increase FOC, increase CV

beta 2– smooth muscle relaxation –> bronchodilation

Question 7

Epinephrine

Dose/Route

Answer 7

Cardiac arrest: 1 mg q 3-5 min 1:10,000 IV

Severe bronchospasm, Anaphylaxis: 0.3-0.5 mg of 1:1000 solution IM may repeat every 15 to 20 minutes; or 1:10,000 solution and give 0.1 mg every 5 minutes IV/IO

Bradycardia, Hypotension: 1 mg in 250 mL of NS 2-10 mcg/min titrated to desired hemodynamic response

Croup: 3 mg 1:1000 mixed in 3 mL NS via SVN

Question 8

Epinephrine

Side Effects

Answer 8

Hypertension –> stroke –> afterload

Increased myocardial O2 demand –> ischemia/ AMI Tachydysrhythmias

Question 9

Epinephrine

Notes on Administration

Answer 9

Never give with Bicarb.

May not be effective in Acidosis or Hypothermia.