epileptic Flashcards
carbamazepine
na block
focal seizure* general tonic clinic trigeminal neuralgia and bipolar disorder
CYP inducer
hyponatremia/stevenjohnson syndrome/blood dyscrasia
eslicarbazepine
block na
partial onset seizures in adults
ethosuximide
T-type ca inhibited
only absence seizures
ezogabine
open m type k channels
QT prolongation blue skin discolor retina changes
BZD
bind to gaba inhibitoryreceptors
avoid gen tonic clonic
clonazepam diazepam clobazam
felbamate (BROAD)
block na glycine(NMDA),Ca inc GABA CYP2C19 inhibitor CYP3A4 inducer used in REFRACYIVE EPILEPSY(Lennox gas taut syndrome)APLASTIC ANEMIA AND HEPATIC FAILURE
GABAPENTIN
enhance gaba
FOCAL SEIZURES TRIGEMINAL NEURALGIA adjunct
OLD people PARTIAL SEIZURES
lacosamide
block na
bind to CRMP-2(collapsin)
treat FOCAL SEIZURES
CRMP-2
PHOSPHOPROTEIN INVOLVED IN NEURONAL DIFFRENTIATION AND CONTROL OF AXONAL OUTGROWTH
LAMOTRIGINE(B)
Block ca and na
wide types-focal ,general ,absence,lennox gestalt and bipolar.
metabolism UGT PATHWAY
UDP METABOLISM DRUGS
DIVAPREX
EZOGABINE
LAMOTRIGINE
LORAZEPAM
LEVITIRACETAM(B)
adjunct FOCAL ONSET MYOCLONIC PRIMARY TONIC CLONIC high affinity to synaptic vesicle protein(SVA2) mood alter
Oxcarbazepine
PRODRUG reduce to MHD
block na and ca in children and adults
PARTIAL ONSET SEIZURE hyponatremia limits use in elderly
Perampanel
partial onset seizures in 12 years old
PHENOBARBITOL AND PRIMIDONE
Enhance GABA
primi to phenobarbitals
treat STATUS EPILEPTICUS
STATUS EPILEPTICUS
two or more seizures occurs without recovery of full consciousness in between episodes
give bzd the phenytoin
STEVEN JOHNSON INDUCIING DRUGS
P heno C aram P hey L amor A llo P eni S ulfa E myth
PHENYTOIN
fosphenytoin (pro)
block na
treat FOCAL GEN AND SATTUS ELLIPTICUS
CYP inducers
gingival hyperplasia/neuropathies/ataxia/osteoporosis
Pregabalin
binds to alpha-delta of calcium block treat FOCAL ONSET POSTHERPETIC NEURALGIA FIBROMYALGIA renal toxic/weight/edema
Rufinamide
TREAT LENNAUX GESTAUT OVER 4 YRS
short QT syndrome common
LENNAUX GASTAUT SYNDROME
divaproleux/lamotrigine/topiramate
is a severe form of epilepsy that typically becomes apparent during infancy or early childhood. Affected children experience several different types of seizures most commonly atonic, tonic and atypical absence seizures.
TIGABINE
Block gaba uptake
treat PARTIAL ONSET SEIZURES
TOPIRAMATE(B)
BLOCK Ca Na CARBONIC ANHYDRASE INHIBITOR,NMDA
TREAT PARTIAL AND PRIMARY GENRERALIZED EPILEPSY also migrane
INHIBITS CYP2C19
SIDE EFFECTS-WEIGHT LOSS/RENAL STONES/HYPERTHERMIA/GLAUCOMA
VALPROIC ACID /DIVAPROLEUX
block na and gaba transaminase
treat focal and primary generalized
inhibit CYP/UGT and epoxide hydroxyls
VIGABATRIN
IRREVERSIBLE inhibitor of GABA-T
visual field loss
ZONISAMIDE(B)
block na and T-Ca
has carbonic anhydrase activity
treat FOCAL EPILEPSY
KIDNEY STONES/OLIGOHYDROSIS
FOCAL
SIMPLE PARTIAL COMPLEX PARTIAL
LAMOTRIGINE
LEVITERACETUM
TOPIRAMATE
SIMPLE PARTIAL
NO LOSS of conciousness
one limb movement
complex partial
sensory hallucinations
motor dysfunction
mental distortion
generalized seizures
tonic clonic
absence
myoclonic
atonic
tonic clonic
loss of conciousness cont contraction and rapid cont and relaxation hypoglycemic LAMOTRIGINE LEVITERACETUM TOPIRAMATE
absence
brief abrupt self limiting loss of consciousness
atare and rapid eyeblinking
from 3-5 years of age for 3 sec
divaproex/limotrigine
myoclonic
brief jerks of limbs
3-5 mins
divaproex/levitiracetum
atonic
drop attacks
sudden loss of muscle tone
west syndrome
infantile spasms
CORTICOTROPHIN
VIGABACTRIN
BENIGN ROLANDIC
gabapentin
lamotrigine
