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Kelly > Epilepsy and HA > Flashcards

Epilepsy and HA Flashcards

1
Q

carbamazepine

A

indications: CPS, GTCS, mixed seizure patterns; trigeminal neuralgia; Bipolar I
Hepatic inducer/autoinducer
Decrease HBC efficacy; preg cat D

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2
Q

Complex partial seizure

A

CPS; awareness of consciousness is impaired)

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3
Q

partial seizures

A

PS; awareness or consciousness is not impaired

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4
Q

generalized tonic-clonic seizure

A

GTCS; bilateral hemispheres

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5
Q

status epilepticus

A

SE

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6
Q

clobazam

A

indications: LGS; anxiety, alcohol withdrawal syndrome
Weak 3A4 inducer
Decreases HBC efficacy; preg cat C

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7
Q

ethosuximide

A

indications: absence

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8
Q

ezogabine

A

indications: PS (adjunctive)

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9
Q

felbamate

A

indications: GTCS, PS, LGS (adjunctive)
2C19 inhibitor; 3A4 inducer
Decreases HBC efficacy; preg cat C

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10
Q

fosphenytoin

A

indications: GTCS, PS, SE
Hepatic inducer
Decreases HBC efficacy; preg cat D

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11
Q

gabapentin

A

indications: PS (adj); pain, postherpetic neuralgia

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12
Q

lacosamide

A

indications: PS (adj)

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13
Q

lamotrigine

A

indications: GTCS, PS, LGS (adj); trigeminal neuralgia, bipolar I
HBC decreases efficacy of lamotrigine and lamotrigine decreases efficacy of progesterone-only OC; preg cat C

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14
Q

levetiracetam

A

indications: PS (adj), myoclonic, GTCS, primary GTCS

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15
Q

oxcarbazepine

A

indications: PS; bipolar I, trigeminal neuralgia
at doses greater than 1200mg: 3A4/5 inducer; 2C19 inhibitor
Decreases HBC efficacy at higher doses; preg cat C

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16
Q

perampanel

A

indications: PS (adj for ages > or equal to 12)

Decreases HBC efficacy at higher doses; preg cat C

17
Q

phenobarbital

A

indications: GTCS, PS, SE, Myoclonic; insomnia
Hepatic inducer
Decreases HBC efficacy; preg cat D

18
Q

phenytoin

A

indications: GTCS, PS, SE; trigeminal neuralgia
Hepatic inducer
Decreases HBC efficacy; preg cat D

19
Q

pregabalin

A

indications: PS (adj); diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia

20
Q

primidone

A

indications: GTCS, PS; essential tremor
Hepatic inducer
Decreases HBC efficacy; preg cat D

21
Q

rufinamide

A

indications: LGS (adj), PS
Weak 3A4 inducer; wear 2E1 inhibitor
Decreases HBC efficacy; preg cat C

22
Q

tiagabine

A

indications: PS (adj)

23
Q

topiramate

A

indications: 2 years and up: LGS (adj), PS, GTCS; migraine prophylaxis, neuropathic pain, essential tremor, weight loss
At doses greater than 200mg: inhibit 2C19; induce 3A4
Decreases efficacy of ethinyl estradiol at higher doses; preg cat D

24
Q

valproate

A

indications: GTCS, PS, Absence; migraine prophylaxis, trigeminal neuralgia, bipolar
Hepatic inhibitor
HBC may decrease levels of valproic acid by 20%; preg cat D

25
Q

vigabatrin

A

indications: refractory CPS (adj), infantile spasm

Mild 2C9 inducer

26
Q

zonisamide

A

indications: PS (adj)

27
Q

newly diagnosed partial seizures

A

first line: carbamazepine, gabapentin, lamotrigine, oxcarbazepine, phenobarb, toipramate, valproate, lacosamide (not in guidelines)

28
Q

partial seizures (refractory)

A

first line: lamotrigine, topiramate, zonisamide

29
Q

partial seizures (refractory adjunctive)

A

first line: gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate

30
Q

generalized seizures

A

first line: lamotrigine, topiramate

31
Q

absence seizures

A

first line: ethosuximide, lamotrigine

32
Q

infantile spasms

A

fist line: vigabatrin (not in guidelines)

33
Q

Lennox-Gastaut Syndrome

A

first line: rufinamide ( not in guidelines)

34
Q

Cluster h/a

A

sudden, stabbing, unilateral, can occur during sleep, occur in clusters for weeks to months, then remission
Therapy: oxygen, triptans (first line), ergotamines, intranasal lidocaine
Preventative: short term: corticosteroid burst, methysergide, ergotamines. long term: verapamil, lithium, AEDs (gabapentin, topiramate, valproic acid), melatonin

35
Q

Tension-type h/a

A

dull and bandlike pain, bilateral, attacks on 15 days/month or more
Therapy: analgesics, NSAIDs, combo (+/- caffeine)
Prevenative: TCAs, SSRIs, SNRIs, mirtazapine

Kelly (12 decks)

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