epilepsy

Question 1

phenytoin
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A phenytoin blood level : 35 mcg/mL

Answer 1

Slurred speech

The therapeutic phenytoin level is 10 to 20 mcg/mL. At a level higher than 20 mcg/mL, involuntary movements of the eyeballs (nystagmus) appear. At a level higher than 30 mcg/mL, ataxia and slurred speech occur.

Question 2

carbamazepine for prophylaxis of complex-partial seizures
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adverse effect?

Answer 2

White blood cell count 3200 mm3

Adverse effects of carbamazepine appear as blood dyscrasias, including aplastic anemia, agranulocytosis, thrombocytopenia, and leukopenia. Other adverse effects include cardiovascular disturbances, thrombophlebitis, dysrhythmias, and dermatological effects. A low white blood cell count would indicate an adverse effect. The values noted in options 1, 2, and 3 are normal values.