Epilepsy

Question 1

MOA of phenobarbital (barbiturate)

Answer 1

GABA potentiation

Question 2

MOA of phenytoin (Dilantin)

Answer 2

Alter multiple channels

Question 3

route of administration of phenytoin

Answer 3

IV, PO

Question 4

Drug of choice for Tonic-Clonic and Partial seizures

Answer 4

Carbamazepine

Question 5

MOA of carbamazepine

Answer 5

Alters sodium channels

Question 6

MOA of Valproate

Answer 6

• Affects sodium channels
• Increases GABA availability to synapses

Question 7

which anti-epileptic drug has the broadest spectrum

Answer 7

Valproate

Question 8

MOA of gabapentin

Answer 8

*Amino Acid analog of GABA
*Unclear - may alter GABA metabolism, transport, or re-uptake

Question 9

drugs for partial seizure

Answer 9

Gabapentin
Valproate

Question 10

MOA of Ethosuximide

Answer 10

Blocks Calcium entry

Question 11

drugs for absence seizures

Answer 11

Ethosuximide
Valproate

Question 12

MOA of Clonazepam

Answer 12

Increases GABAergic neurotransmission mediated by GABAa receptors

Question 13

List the newer drugs for epilepsy

Answer 13

Vigabartin
Tiagabine
Lamotrigine
Topiramate

Question 14

List the newer drugs for epilepsy

Answer 14

Vigabartin
Tiagabine
Lamotrigine
Topiramate

Question 15

Tx of Status Epilepticus

Answer 15

Benzodiazepine:
Diazepam IV 5-10 mg (1-2 mg/min)
Lorazepam IV 2-6 mg (1 mg/min)
OR
IM Midazolam

Question 16

Which anti-epileptic drugs cannot be given to pregnant patients

Answer 16

Valproic acid
Phenytoin
Carbamazepine