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DDS3 PHARM - CNS > Depression > Flashcards

Depression Flashcards

1
Q

what are the 4 categories of drugs for depression

A
  • Tricyclic Antidepressants (TCAs)
  • Selective Serotonin Reuptake Inhibitors (SSRIs)
  • Monoamine Oxidase Inhibitors (MAOIs)
  • Atypical Antidepressants (others)
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2
Q

list TCAs

A

Amitriptyline (Elavil)
Imipramine (Tofranil)
Trimipramine (Surmontil)
Nortriptyline (Aventyle)
Protriptyline (Vivactil)
Desipramine (Pertofrane)

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3
Q

MOA of TCAs

A

Block the presynaptic reuptake transporter for norepinephrine and/or serotonin

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4
Q

where do most of TCA’s side effects come from

A

Block the postsynaptic receptors for histamine, ACh and NE

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5
Q

List SSRIs

A

Fluoxetine (Prozac)
Sertraline (Zoloft)
Paroxetine (Paxil)
Fluvoxamine (Luvox)
Citalopram (Celexa)

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6
Q

MOA of SSRIs

A

Selectively inhibit 5-HT (not NE) uptake

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7
Q

what type of drug is used for initial treatment of depression

A

SSRIs

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8
Q

what type of drug is the last choice for depression

A

MAOI

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9
Q

MOA of MAOI

A

decrease in degradation of dopamine, serotonin, and NE

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10
Q

list MAOIs

A

Phenelzine (Nardil)
Tranylcypromine (Parnate)
Selegiline (Eldepryl)

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11
Q

MOA-A is responsible for

A

NE

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12
Q

MOA-B is responsible for

A

serotonin

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13
Q

what is the name of a Serotonin and Noradrenaline Reuptake Inhibitors (SNRI)

A

Venlafaxine

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14
Q

what is Venlafaxine used for

A

depression
depression with anxiety
generalized anxiety disorders
social phobias
neuropathic pain

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15
Q

NOA of Venlafaxine

A

▪ pharmacodynamics like in TCA
▪ improved profile of adverse reactions

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16
Q

what is the name of a Noradrenaline and Dopamine Reuptake Inhibitors (NDRI)

A

Bupropion (Wellbutrin; Zyban)

17
Q

what is bupropion used for

A

severe depression + smoking cessation treatment

18
Q

what is the name of a Serotonin Antagonists/Reuptake Inhibitors (SARI)

A

Trazodone

19
Q

what is trazodone used for

A

depression with significant anxiety and sleep disturbances

DDS3 PHARM - CNS (3 decks)

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