epigenetics Flashcards
1
Q
what is epigenetics
A
a heritable change in gene function without change to the base sequence of DNA
2
Q
increased methylation of DNA affect gene transcription
A
- addition of methyl group
- prevent TF from binding
- transcription is suppressed
3
Q
decreased acetylation of DNA affect gene transcription
A
- charged histones bind to - charged DNA
- decreasing acetylation increases + histones
- binding becomes too tight
- prevents transcription factors from accessing DNA
- transcription is suppressed
4
Q
how might epigenetic change affect humans
A
- cause dieses
- by activating gene function or by suppressing it
