Epidemiology, Infections and Communicable Disease Flashcards
What is the latency period?
replication before shedding
What is the interval between invasion by an infectious agent and the first appearance of S/S of disease?
incubation period
What is the interval during which an infectious agent may be transferred?
communicable period, usually starts before start of S/S
What is the incubation and communicable period for chicken pox?
- 2-3 wks
- 1-2 days before development of a rash, until lesions crust over (appx. 5 days)
Signs of a localized infection?
inflammation, redness, warmth, selling, pain/tenderness, loss of function, drainage, cellulitis
Signs of generalized infection?
weakness, HA, malaise, fever, increases pulse, hyhpotension
When are neutrophil counts increased?
in most bacterial infections
Increased eosinophils are indicative of what?
an allergic reaction
Lymphocytes are increased in which diseases?
chickenpox, mumps, measles, mono, viral hepatitis (viruses)
When will Monocytes be increased?
TB and in the convalescent phase of acute infections
What does the term “shift to the left” indicate?
active infection with an increased number of immature neutrophils
What is C-Reactive Protein an indicator of?
inflammation
Sedimentation rate is a marker of what?
inflammation and infection
What is it called when a disease or condition is regularly found in a particular area/population?
an endemic
What is a secular pattern of disease?
long-term patterns, greater than 10 yrs
What is a point epidemic?
time and space related event (ex. food poisoning at a picnic)
What is a cyclical pattern of disease?
seasonal fluctuations (flu/cold)
People having reactions to the same vaccine at different places and at different times is an example of what type of disease pattern?
Event-related cluster
What factors make up the epidemiologic triangle?
Host, Agent, environment
Definition of “agents” of disease?
causes of the disease (bacteria, poison, cholesterol)
What is a prevalence rate?
number of all cases of a specific disease at a given point in time
What is an incidence rate?
number of new cases in a population in a specified period of time
How to calculate the incidence rate?
(new cases at a specified period in time/total population at risk) x factor (1, 10, 100…)
How to calculate the prevalence rate?
(existing cases at a specified period in time/totoal population at risk) x a factor (10, 100….)
What is an attack rate?
proportion of persons exposed to an agent and who develop the disease
How to calculate the attack rate?
- (number of cases/ total population exposed) x 100
- is listed as a percentage
What is the term for the probability of an event occurring in the exposed group versus the control (non-exposed) group?
relative risk (RR)
How to calculate the relative risk?
RR = incidence of disease in exposed population/incidence of disease in non-exposed or control population
What are the stages of the natural history of disease?
1) pre-exposure (risk factors present for disease)
2) pre-pathogenesis or preclinical stage (exposure to causative agent)
3) pathogenesis (disease is present)
4) resolution (problem resolved)
Stages of HIV?
1) primary infection (< 1 month)
2) clinical latency (no symptoms)
3) symptomatic disease (AIDs)
What is the definition of sensitivity in a screening test?
quentifies ho accurately the test identifies those WITH the condition or trait (true positives)
What is the definition of specificity in a screening test?
indicates how accurately the test identifies those WITHOUT the condition or trait (true negatives)
How is the validity of a screening test measured?
by specificity and sensitivity