Epidemiology Flashcards

1
Q

What is epidemiology?

A

‘the study of that which Is upon people’

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2
Q

What does endemic mean?

A

Diseases that reside within a population

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3
Q

What does epidemic mean?

A

Diseases that befall a population

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4
Q

How is epidemiology defined?

A

The study of the distribution and determinants of health-relates states or events in specified populations, and the application of this study to the control of health problems

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5
Q

Give a more succinct definition of epidemiology

A

How often disease in different groups of people and WHY

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6
Q

What are the three types of prevention?

A

Primary
Secondary
Tertiary

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7
Q

What is primary prevention?

A

The prevention of disease through the control of exposure to risk factors

before onset of disease

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8
Q

What is secondary prevention?

A

The application of available measures to detect early departures from health and to introduce appropriate treatment and interventions

slows progression

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9
Q

What is tertiary prevention?

A

The application of measures to reduce or eliminate long-term impairments and disabilities, minimising suffering caused by existing departures from good health and to promote the patient’s adjustments to their condition.

e.g. rehabilitation of someone who has had a stroke
enabling return to normal function

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10
Q

What does being good at epidemiology involve?

A
Curiosity
Problem-solving
Numerical ability 
Critical thinking 
Communication 
Creativity
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11
Q

What are the three dimension of epidemiology?

A

Time
People
Place

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12
Q

What two things are often studied in epidemiology?

A

Exposures and Outcomes

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13
Q

What does the demographic transition model consist of?

A

5 stages of progression looking at birth rate, death rate and total population

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14
Q

What are the four stages of epidemiological transition?

A

Pestilence and famine
Receding pandemics
Degenerative man-made diseases
Delayed degenerative diseases and emerging infections

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15
Q

When was the era of pestilence of famine occurring the UK?

A

Pre-industrial revolution (up to 1800s)

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16
Q

What was associated with this period of pestilence and famine?

A

Urbanisation
Constraints on food supply
High birth rate and high mortality
Life expectancy low at birth

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17
Q

When was the era of receding pandemics occurring the UK

A

1800s - 1950

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18
Q

What was associated with this receding pandemics and famine?

A

Agricultural development improves nutrition

Life expectancy increases

Water, sanitation, hygiene

Vaccination emerges

High birth rate and decreasing deaths

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19
Q

When was the era of degenerative diseases occurring the UK?

A

1950 -2010s

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20
Q

What was associated with this degenerative and man-made disease period?

A

Lifestyle factors and NCDs predominate: Cancer and CVD

Environmental and global determinants drive obesity and other risk factors

Technology reduces need for physical labour

Addiction, violence and other issues emerge

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21
Q

When was the era of delayed degenerative diseases and emerging infections occurring the UK?

A

2010s onwards

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22
Q

What was associated with this degenerative and man-made disease period?

A

Health technology defer morbidity, albeit at increasing financial cost

Emerging zoonotic disease presents new threats

Inequalities within and between countries come to the fore

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23
Q

What determines which stage a country falls under?

A

Access to food, water, healthcare and sanitation

24
Q

What are the levels of evidence?

A

The pyramid

Systematic reviews and meta-analysis

Randomised control trials

Cohort Studies

Case-control studies

Case series, case reports

Editorial, Expert opinion

25
What are the two types of research?
Quantitative research | Qualitative research
26
What are the different types of epidemiological approach?
Descriptive Analytic
27
What does qualitative research often explore?
Underlying ideas and themes to inform research questions and possible future hypotheses
28
How to does qualtitative research express findings?
In words
29
What are the main pros and cons of qualitative research?
Relies on small numbers participants Goes into substantial details
30
When is qualitative research often used?
Earlier in the research process
31
What are the three groups of conditions that affect DALYs?
Communicable disease Non-communicable disease Injuries
32
Give 4 measures of frequency
Odds Prevalence Cumulative incidence Incidence rate
33
What are odds?
Ratio of a probability of an event to its complement Number of people who have the disease divided by the number of people who don't have the disease
34
What is prevalence?
Proportion of individuals in a population who have the disease or attribute of interest at a specific timepoint Number of people with the disease divided by the population Always need to specify timepoint Prevalence is measure with a percentage Provides no information on new cases of a disease
35
What is cumulative incidence?
Proportion of the population with a new event during a given time period Number of new cases during the period of interest divided by the number of disease-free individuals at the start of this time period Need to be explicit about time period
36
What does a cumulative incidence value of 0 mean?
There were no new cases during the study period
37
What does a cumulative incidence value of 1 mean?
All individuals developed the disease during the time period
38
What are other names for cumulative incidence?
Incidence proportion | Risk
39
What must happen to calculate cumulative incidence?
Follow up from participants in study At the same time No new participants can join No participants should leave
40
What is incidence rate?
Number on new cases per unit of person time The number of new cases during the follow up period divided by the total person-time by disease-free individuals Can take values from 0 to infinity Must mention unit of person time Suitable for studies when people enter/leave study at different times
41
What is person-time?
The total time a participant spends in the study Can be expressed in various units hours-years Ends when person acquires disease, dies or is lost to follow up
42
What does standardisation allow us to do?
Make comparison | Adjusting for factors
43
What are the two types of standardisation?
Direct Standardisation | Indirect Standardisation
44
What does direct standardisation give you?
Comparable incidence e.g. 120 stroked per 100,000 a year
45
What does indirect standardisation give you?
Gives a ration out of 100
46
What does direct standardisation allow us to do?
Compare like-for-like between populations E.g. look ate age-specific incidence in a standard population
47
How would you conduct direct standardisation?
Step one: Calculate rate for each age bin Step two: Add standard population to table Step three: Rate x standard population divided by 100k to obtain expected count Step 4: Take expected and divided by total population to get age-standardised incidence
48
What is important to note about every stat?
Potentially hiding another fact
49
A hospital has a seemingly high post-elective surgery 30 day mortality. What are the three possible explanations?
Unwanted variation - Hospital A is dangerous Explained variation - e.g. the hospital does more high risk procedures Statistical artefact - hospital is better at recording deaths (can be difficult to explain deaths outside of a hospital)
50
How do you conduct indirect standardisation?
Use national statistics to calculate expected values Calculate SMR
51
What is the SMR?
Standard mortality ration
52
How do you calculate SMR?
Dividing the observed count by the expected count
53
What is SIR?
Standardised incidence ratio
54
What is SHMI data?
Summary hospital mortality indicator data
55
When is indirect standardisation useful?
When we only have high-level data about outcomes We cannot make direct comparison First step on a journey of enquiry
56
What does the SHMI do?
indirect standardisation to produce ‘expected’ number of deaths by a series of adjustments taking into account the volume of cases blend of diagnoses casemix adjustments for underling demography and health status variation of patients
57
What doe SHMI values range from?
0.6 - 1.2