Eosinophils Flashcards
In which “normal” non-inflamed tissues are eosinophils normally found?
GI tract (lamina propria), lungs, adipose tissue, thymus, uterus, mammary glands
What is the most common non-neoplastic nodular skin disease in horses
Equine Eosinophilic Granuloma
Eosinophils are associated with what type of Hypersensitivity (e.g. I-IV)?
Type I Hypersensitivity
Name 3 stains with an affinity for eosinophil granules.
Eosin, Giemsa, Luna
Which eosinophil granule protein is responsible for the creation of free radicals (reactive oxygen and nitrogen species)?
Eosinophil Peroxidase (EPO)
Which two interleukins, associated with a Th2 response, enhance integrin formation on eosinophils?
IL-4 and IL-13
Which 3 leukotrienes are responsible for vasoconstriction, bronchospasm, and increased vascular permeability?
LTC4, LTD4, LTE4
You see a kitty with a red, swollen, crusty alopecic nose. You do cytology looking for cryptococcus, but instead of fungal organisms you see a bunch of eosinophils. Diagnosis?
Feline mosquito bite hypersensitivity
One mechanism by which glucocorticoids lower eosinophil counts is death by __________.
apoptosis
Name the 4 pathways of eosinophil degranulation
Classical exocytosis, compound exocytosis, piecemeal degranulation, cytolysis
Which is more important for eosinophil activation in allergic disease, IgA or IgE?
IgA
Which two cell types make up the “allergic-effector unit”?
Eosinophils and Mast Cells
What animals get Chediak-Higashi aside from Persian cats?
Aleutian mink, Hereford cattle, rats, mices, orcas, white tigers
Name a common location on the body to find eosinophilic plaques.
Ventral abdomen, thighs
Which IgA receptor is the most potent stimulant of eosinophil degranulation?
FCaR (CD89)
What breed is over-represented in Wells-like Syndrome?
Labrador Retrievers
Is wound healing accelerated or delayed by the presence of eosinophils and eosinophil granule proteins?
Delayed
Which are the three most prevalent cytokine receptors on the surface of eosinophils?
IL-3, IL-5, GM-CSF
What does NAACP stand for (with regards to feline hypereosinophilic syndrome)?
Neoplasia, Allergy, Asthma, Churg-Strauss/Connective tissue dz, Parasitism
Which growth factor, produced and secreted by eosinophils, promotes mast cell activation and survival?
Nerve Growth Factor (NGF)
Name the 3 presentations of eosinophilic granuloma complex
eosinophilic/rodent ulcer, eosinophilic plaques, eosinophilic/linear granuloma
Which granulocyte-monocyte precursor is most important for eosinophil lineage specification?
GATA-1
What is a hallmark histopath finding for equine eosinophilic granuloma?
Collagen flame figures
Which breeds of dogs lack visible granules in their eosinophils (and have vacuoles)?
Greyhounds, sight hounds, +/- golden retrievers