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Women's Health Rotation > EOR pharm part 2 > Flashcards

EOR pharm part 2 Flashcards

1
Q

Dosage forms of Tylenol with codeine

A

Tablet

PO suspension

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2
Q

Average daily dosages of Tylenol with codeine

A

Cough: 1/2t-1t every 4-6 hours
Pain: 1-2t every 4-6 hours

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3
Q

Common indications of Tylenol with codeine

A

Relief of mild-to-moderate pain

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4
Q

MOA of Tylenol with codeine

A

Acetaminophen: Although not fully elucidated, believed to inhibit the synthesis of prostaglandins in the central nervous system and peripherally block pain impulse generation; produces antipyresis from inhibition of hypothalamic heat-regulating center.
Codeine: Binds to opiate receptors in the CNS, causing inhibition of ascending pain pathways, altering the perception of and response to pain; causes cough suppression by direct central action in the medulla; produces generalized CNS depression

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5
Q

Common adverse effects of Tylenol with codeine

A 
Hepatotoxicity
Steven Johnson syndrome
Constipation
Dizziness/drowsiness
HA
Lightheadedness
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6
Q

Renal or hepatic dose adjustments of Tylenol with codeine

A

Hepatic: use with caution may cause hepatotoxicity

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7
Q

BBW for Tylenol with codeine

A

Hepatotoxicity and ultra-rapid metabolism of codeine to morphine

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8
Q

Clinically sig drug interactions of Tylenol with codein

A

EtOH

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9
Q

Major counseling points of Tylenol with codeine

A

Do not use any other product including OTC with APAP
Avoid alcohol
Do not exceed 3-4gm/day of APAP

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10
Q

Monitoring parameters of Tylenol with codeine

A

Pain control
Constipation
Abuse
Misuse

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11
Q

Dosage forms of risperidone

A

Tablets, Orally disintegrating tabletsRISPERDAL® M-TAB® Orally Disintegrating Tablets 0.5 mg, 1 mg, 2 mg, 3mg, 4mg,
Powder for injection
Oral solution

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12
Q

Average daily dosages of risperidone

A

Oral: 1mg BID on day 1, 2mg BID on day 2, 3mg BID on day 3, then titrate on a weekly basis. Max dose: 16mg
Injection: 25mg IM every 2 weeks

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13
Q

Common indications of risperidone

A 
Bipolar mania
Bipolar I maintenance
Schizophrenia
PTSD
Tourette's syndrome
Agitation
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14
Q

MOA of risperidone

A

Dopamine (D2) and serotonin (5HT2) antagonism

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15
Q

Common adverse effects of risperidone

A 
EPS
Tachycardia
Priapism
Rash
Somnolence
Agitation/anxiety
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16
Q

Renal or hepatic dose adjustments for risperidone

A

Renal and hepatic adjustments recommended

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17
Q

BBW in risperidone

A

Increased mortality in elderly pts with dementia-related psychosis

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18
Q

Drug interactions with risperidone

A

Fluoxetine, carbamazepine, and clozapine may increase risperidone

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19
Q

Major counseling points of risperidone

A

May cause fainting during initial doses
May impair judgement
Avoid EtOH
Avoid excessive exposure to sunlight and heat during therapy

20
Q

Monitoring parameters of risperidone

A

Decrease S/sx of bipolar, schizophrenia, PTSD, and Tourettes

21
Q

Dosage forms of quetiapine

A

Tablets (25mg, 50mg, 100mg, 200mg, 300mg, 400mg)

Tablets, extended-release, XR (50mg, 150mg, 200mg, 300mg, 400mg)

22
Q

Average daily dosages of quetiapine

A

Maintenance dose should be between 300 and 400 mg daily, given in two to three doses or one extended-release tablet; Max 800 mg per day

23
Q

Common indications for quetiapine

A

Tx of schizophrenia
Tx of depressive episodes associated with bipolar d/o
Tx of MDD
PTSD

24
Q

MOA of quetiapine

A

Combination of dopamine type 2 (D2) and serotonin type 2 (5-HT2) antagonism

25
Q

Common adverse effects of quetiapine

A 
Somnolence
Dizziness
Constipation
Postural hypotension
Dry mouth
Dyspepsia
26
Q

Renal or hepatic dosage adjustments for quetiapine

A

Hepatic impairment- initiate 25mg/day then step up daily in increments of 25-50mg/day

27
Q

BBW of quetiapine

A

Increased mortality in elderly patients with dementia-related psychosis.
Increased suicidal thoughts and behavior

28
Q

Clinically sig drug interactions with quetiapine

A

May have additive sedative effects with other CNS depressants. \
Oral clearance is increased with phenytoin and thioridazine.
Chronic use with NSAIDS increases risk of GI bleed

29
Q

Major counseling points of quetiapine

A

Caution when rising from a prone position.
May cause drowsiness- use caution when performing tasks that require alertness. May be taken without regards to food.
Seroquel XR should be swallowed whole and not crushed, divided, or chewed.

30
Q

Monitoring parameters of quetiapine

A

Decrease in shizophrenic/bipolar/depressive episodes
Unusual changes in mood
Suicidality

31
Q

Dosage forms of metronidazole

A 
IV: 500mg/100ml 
Capsule: 375mg 
Tablet: 250, 500mg 
Cream: 0.75% 
Gel: 0.75, 1% 
Lotion: 0.75% 
Vaginal Gel: 0.75%
32
Q

Average daily dosages of metronidazole

A

250-1000 mg/day

33
Q

Common indications of metronidazole

A

Various infections

34
Q

MOA of metronidazole

A

Metronidazole inhibits anaerobic bacterial DNA synthesis leading to bacterial death

35
Q

Common adverse effects of metronidazole

A 
Vaginitis
Abdominal discomfort
Diarrhea
Nausea
Taste disturbance
36
Q

BBW of metronidazole

A

Carcinogenic

37
Q

Drug interactions of metronidazole

A

When taken with zipasidone QT prolongation may be seen

38
Q

Major counseling points of metronidazole

A

NO EtOH

39
Q

Monitoring parameters of metronidazole

A

Improvement in S/sx of infection

WBC

40
Q

Dosage forms of fluconazole

A

Tabs
PO suspension
Injectable solution

41
Q

Average daily dosages of fluconazole

A

100-800 mg daily (depending on indication)

42
Q

Common indications of fluconazole

A

Treatment of candidiasis (esophageal, oropharyngeal, peritoneal, urinary tract, vaginal)
Systemic candida infections (eg, candidemia, disseminated candidiasis, and pneumonia); Cryptococcal meningitis
Antifungal prophylaxis in allogeneic bone marrow transplant recipients

43
Q

MOA of fluconazole

A

Interferes with fungal cytochrome P450 activity (lanosterol 14-α-demethylase), decreasing ergosterol synthesis (principal sterol in fungal cell membrane) and inhibiting cell membrane formation

44
Q

Common adverse effects of fluconazole

A 
HAs
Dizziness
Abd pain
Vomiting
Rash/pruritis
Increase in AST/ALT
45
Q

Renal or hepatic dose adjustments of fluconazole

A

Renal- If CrCl is <50: administer 50% of recommended dose

46
Q

Clinically sig drug interactions of fluconazole

A

Fluconazole is a 34, 2C9 and 2C19 inhibitor (may increase INR in patients on warfarin)

47
Q

Major counseling points of fluconazole

A

Take with or without food
If you are passing brown or dark-colored urine, have pale stools, or feel more tired than usual or skin/sclera turning yellow immediately contact your physician
If you develop a serious rash contact your physician
The liquid suspension should not be refrigerated.

Women's Health Rotation (15 decks)

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