EOR GI part 4- gastric CA, bariatric surgery, SBO Flashcards
What are the associated RFs of gastric CA- diet?
Smoked meats High nitrates Low fruits and veggies EtOH Tobacco
RFs of gastric CA- environmental
Raised in high-risk area Poor SES Atrophic gastritis Male gender Blood type A Previous partial gastrectomy Pernicious anemia Polyps H. pylori
Which blood type is associated with gastric CA?
Blood type A
What are the sx of gastric CA?
Weight loss Emesis Anorexia Pain/epigastric discomfort Obstruction Nausea
What is a Blumer’s shelf?
Solid peritoneal deposit anterior to rectum, forming a “shelf”, palpated on rectal exam
What is a Virchow’s node?
Metastatic gastric CA to the nodes in the left supraclavicular fossa
What is a surveillance lab finding in gastric CA?
CEA elevated in 30% of cases (if pos, useful for post-op surveillance)
What is the initial workup for gastric CA?
EGD with bx Endoscopic u/s to evaluate the level of invasion CT abdomen/pelvis for metastasis CXR Labs
What is the histology of gastric CA?
Adenocarcinoma
What is the DDx for gastric tumors?
Adenocarcinoma Leiomyoma Leiomyosarcoma Lymphoma Carcinoid Ectopic pancreatic tissue Gastrinoma Benign gastric ulcer Polyp
Which morphologic type of gastric CA is named after a “leather bottle”?
Linitis plastica- the entire stomach is involved and looks thickened (10% of cancers)
Which pts with gastric CA are non-operative?
Distant metastasis
Peritoneal implants
What is the role of laparoscopy in gastric CA?
To r/o peritoneal implants and to evaluate for liver metastasis
What is the genetic alteration seen in >50% of pts with gastric CA?
P53
What is the tx for gastric CA?
Surgical resection with wide (>5 cm checked for frozen section) margins and lymph node dissection
What operation is performed for a tumor in the antrum?
Distal subtotal gastrectomy
What operation is performed for a tumor in the midbody?
Total gastrectomy
What operation is performed for a tumor in the proximal?
Total gastrectomy
What is a subtotal gastrectomy?
75% of the stomach removed
What is a total gastrectomy?
Stomach is removed and a Roux-en-Y limb is sewn to the esophagus