EOR #6 pharm part 2

Question 1

Common indications for hydroxyzine

Answer 1

Antiallergy agent
For management of pruritis d/t allergic conditions such as chronic urticaria, atopic dermatoses, and contact dermatoses and in histamine-mediated pruritis, anxiety

Question 2

MOA of hydroxyzine

Answer 2

Competes with histamine for H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract.

Question 3

Common AEs of hydroxyzine

Answer 3

Drowsiness
Dry mouth
HA

Question 4

Renal or hepatic dose adjustments for hydroxyzine

Answer 4

Liver dz: change dosing interval to every 24 hrs

Question 5

Clinically significant drug interactions with hydroxyzine

Answer 5

EtOH

Other CNS depressants

Question 6

Major counseling points for hydroxyzine

Answer 6

May cause drowsiness
Use caution while operating machinery or when mental alertness is required
Avoid EtOH while taking this medication

Question 7

Monitoring parameters for hydroxyzine

Answer 7

Decrease in S/sx of allergic conditions

Improvement in anxiety or sleep

Question 8

Common indications for isosorbide mononitrate

Answer 8

Angina

Question 9

MOA of isosorbide mononitrate

Answer 9

Nitric oxide activates an enzyme which increases cGMP, this dilates large myocardial arteries to increase blood supply to the heart

Question 10

Common AEs of isosorbide mononitrate

Answer 10

HA

Dizziness

Question 11

Clinically significant drug interactions of isosorbide mononitrate

Answer 11

Phosphodiesterase 5 Inhibitors: May enhance the vasodilation effect of organic nitrates Rosiglitazone: Vasodilators may enhance the adverse/toxic effect of Rosiglitazone, specifically, a greater risk of ischemia.

Question 12

Major counseling points of isosorbide mononitrate

Answer 12

Do not take for emergency treatment of acute onset chest pain Scored tablets may be split, but not crushed or chewed
Headaches show signs of drug working
Use Tylenol to treat headache

Question 13

Monitoring parameters of isosorbide nitrate

Answer 13

Decrease in s/sx of angina

Question 14

Common indications for pantoprazole

Answer 14

GERD
PUD
Gastritis

Question 15

MOA of pantoprazole

Answer 15

Suppresses final step in production of gastric acid at secretory surface of the gastric parietal cell

Question 16

Common AEs of pantoprazole

Answer 16

Diarrhea
HA
Flatulence
Rash

Question 17

Major counseling points of pantoprazole

Answer 17

May be taken without regard to meals
Swallow tablet whole – do not split, chew or crush
Granules should be mixed with applesauce or apple juice and swallowed immediately, Antacids may be taken at the same time
Store in a cool dry place away from kids and sunlight
If you miss a dose, take it as soon as possible, if it is closer to the next dose, skip the missed dose and return to normal dosing schedule – do not double doses

Question 18

Monitoring parameters of pantoprazole

Answer 18

Improvement in GI s/sx

Mg with long-term use

Question 19

Common indications of doxycycline

Answer 19

Various infections

Question 20

MOA of doxycycline

Answer 20

Doxycycline binds to the 30S subunit on the ribosome and inhibits binding of the aminoacyl-t-RNA molecules

Question 21

Common adverse effects of doxycycline

Answer 21

Photosensitivity
Diarrhea
Nasopharyngitis

Question 22

Major counseling points for doxycycline

Answer 22

Avoid antacids and calcium containing foods upon administration of medication
Avoid excess sun exposure
Take with full glass of water

Question 23

Clinically significant drug interactions of doxycyline

Answer 23

Use with digoxin could increase the levels of digoxin within the body

Question 24

Monitoring parameters of doxycycline

Answer 24

Improvement of s/sx of infection

WBC