EOR #6 pharm part 1 Flashcards

1
Q

Common indications for tiotropium

A

COPD

Asthma

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2
Q

MOA for tiotropium

A

Antagonizes binding of acetylcholine to M3 receptors on bronchial smooth muscle, resulting in bronchodilation which lasts greater than 24 hrs

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3
Q

Common adverse effects of tiotropium

A
Dry mouth 
Pharyngitis
Sinusitis 
Upper RTI
Throat irritation
Hoarseness
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4
Q

Clinically significant drug interactions of tiotropium

A

Use with either bupropion or donepezil could lower the seizure threshold

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5
Q

Major counseling points of tiotropium

A

Store in a cool dry place away from kids and sunlight Unused capsules should remain in the blister strip and be used over the next 2 days If a dose is missed, take it as soon as possible – if it is closer to the time of your next dose than the missed dose, skip the missed dose and return to the normal dosing schedule
Use daily for maximum effectiveness
How to use product

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6
Q

Monitoring parameters of tiotropium

A

Pulmonary function tests
Proper technique
S/sx of asthma/COPD

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7
Q

Common indications for benazepril

A

Tx of HTN, either alone or in combo with other antihypertensives
CHF

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8
Q

MOA of benazepril

A

ACE-I

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9
Q

Common AEs of benazepril

A
Cough
HA
Dizziness
Angioedema
Fatigue
Nausea
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10
Q

Renal or hepatic dose adjustments for benazepril

A

Renal- CrCL <30: initiate at 5 mg

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11
Q

BBW for benazepril

A

Fetal toxicity

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12
Q

Clinically significant drug interactions of benazepril

A

Use of NSAIDs should be avoided or limited, with monitoring of blood pressure control in this setting.
In patients with HF, NSAID use may be associated with an increased risk for fluid accumulation and edema.  ARBs

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13
Q

Major counseling points of benazepril

A

Avoid nonprescription cough, cold, and allergy medications unless otherwise directed
Avoid salt substitutes containing potassium.
Report any sign of angioedema
Let physician know if pregnant or planning on becoming pregnant.

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14
Q

Monitoring parameters of benazepril

A
Decrease in BP
HR
Sx of CHF
SCr
Potassium
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15
Q

Common indications for celecoxib

A

Nonsteroidal anti-inflammatory
For the relief of osteoarthritis Relief of the signs and symptoms of rheumatoid arthritis in adults
For the management of acute pain and dysmenorrhea

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16
Q

MOA of celecoxib

A

Inhibits prostaglandin synthesis by decreasing the activity of the enzyme, cyclooxygenase-2 (COX-2), which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.

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17
Q

Common AEs of celecoxib

A
Diarrhea
Dyspepsia
Abd pain
Flatulence
Edema
Bleeding
18
Q

Renal or hepatic dose adjustments for celecoxib

A

Advanced renal disease: Use is not recommended, Moderate hepatic impairment: Reduce dose by 50%.
Severe hepatic impairment: Use is not recommended.

19
Q

BBW for celecoxib

A

Celecoxib may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction (MI), and stroke, which can be fatal.
NSAIDs, including celecoxib, cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.

20
Q

Clinically significant drug interactions for celecoxib

A

May increase the effects of warfarin

21
Q

Major counseling points of celecoxib

A

May be taken without regards to meals
Report any signs of ulcerations and bleeding to a physician
Avoid ASA or ASA containing products
Pay close attention to sudden mood change and suicidality

22
Q

Monitoring parameters of celecoxib

A

Decrease the S/S of inflammatory conditions, rheumatoid arthritis, dysmenorrhea, improvement in S/S pain

23
Q

Common indications of benzonatate

A

Symptomatic relief of cough

24
Q

MOA of benzonatate

A

Tetracaine congener with antitussive properties Suppresses cough by topical anesthetic action on the respiratory stretch receptors

25
Q

Common AEs of benzonatate

A
Drowsiness
HA
Constipation
Nausea
Pruritis
Nasal congestion
Sensation of burning in the eyes
26
Q

Pregnancy category of benzonatate

A

C

27
Q

Major counseling points of benzonatate

A

Swallow capsule whole- do not chew or dissolve in mouth
Do not exceed prescribed dosage
Contact physician immediately if you have difficulty breathing or swallowing shortly after a dose

28
Q

Monitoring parameters of benzonatate

A

Relief of cough/antitussive effects

29
Q

Common indications of sildenafil

A

Erectile dysfunction

Pulmonary HTN

30
Q

MOA of sildenafil

A

Increases cGMP within vascular smooth muscle cells resulting in relaxation and vasodilation

31
Q

Common AEs of sildenafil

A

Erythema
Flushing
HA

32
Q

Renal or hepatic dose adjustments of sildenafil

A

Renal- CrCl <30: 25 mg/day

Liver disease: 25 mg/day

33
Q

Clinically significant drug interactions of sildenafil

A

Can result in hypotensive crisis when taken with nitrates

34
Q

Major counseling points of sildenafil

A

Seek medical attention if the erection lasts longer than 4 hrs
No more than one dose per day

35
Q

Monitoring parameters of sildenafil

A

Decrease in S/sx of ED/pulmonary HTN

36
Q

Common indications for bupropion

A

Depression
Anxiety (Wellbutrin)
An aid in smoking cessation (Zyban)

37
Q

MOA of bupropion

A

Weak inhibitor of neuronal uptake of NE, serotonin, and dopamine

38
Q

Common AEs of bupropion

A

Tremor
Wt loss
Insomnia

39
Q

Renal or hepatic dose adjustments for bupropion

A

Hepatic/renal: consider reducing dose and frequency

40
Q

BBW for bupropion

A

Suicidality

41
Q

Clinically significant drug interactions for bupropion

A

EtOH may lower seizure threshold
Toxicity is increased by MAO-Is
Chronic use with NSAIDs increases risk of GI bleeds

42
Q

Major counseling points for bupropion

A

Swallow XL and SR tablets whole
Avoid alcohol
Weight loss or gain may be temporary
May need up to 2 weeks to show noticeable improvement
Pay attention to sudden mood/thought change. Do not abruptly discontinue this medication.