EOB Flashcards
Cimetidine
-dine
H2 receptor antagonist
Decrease parietal cell H+ secretion
Use for peptic ulcer, gastritis, mild esophageal reflux
CYP450 inhibitor, anti androgenic, cross to brain and placenta, decrease creatinine secretion
Omeprazole
-prazole
Proton pump inhibitors
Inhibit H/K ATPase
C. Diff risk, pneumonia, decrease Mg long term
Bismuth/sucralfate
Bind ulcer base providing physical protection
Allowing HCO3- secretion
Ulcers, travelers diarrhea
Misoprostol
PGE1 analog
Increase mucus secretion, decrease acid production
Block NSAID peptic ulcer
Diarrhea. BAD FOR PREGNANCY
Ocreotide
Somatostatin analog
Inhibit vasoconstrictive hormones, decrease acid secretion
Nausea, cramps, acromegaly (inhibit GH)
Aluminum hydroxide
Antacid - hypoK
Constipation + low phosphate
Calcium carbonate
Antacid - hypoK
Hypercalcemia
Magnesium hydroxide
Antacid - hypoK
Diarrhea, hypotension, cardiac arrest
Osmotic laxatives
Lactulose, MgOH
Draw water into lumen
Sulfasalazine
Sulfapyridine + 5ASA
Ulcerative colitis, Crohn’s
Ondansetron
5HT3 antagonist, decrease vagal stimulation
Central antiemetic
Control vomiting in cancer chemo patients
QT PROLONGATION
Metoclopramide
1st line prokinetic, D2 receptor antagonist
Increase resting tone, contractility, LES tone
Tardive dyskinesia, fatigue depression
Orlistat
Inhibit gastric/pancreatic lipase
Less breakdown of fats
Rapid actin insulin
Aspart, Glulisine, Lispro
Bind insulin receptor
Glycogen storage, glucose uptake, TG formation
Intermediate insulin
NPH
Long acting insulin
Glargine, Detemir
Metformin
Increase AMPK activity
Glu uptake, decrease gluconeogenesis, increase glycolysis
Sulfonylureas
Close beta cell K channel –> depolarize –> Ca channel open and Ca influx –> Insulin release