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Biochem > Enzymes and Coenzymes > Flashcards

Enzymes and Coenzymes Flashcards

1
Q

Induced fit model a.k.a

A

Daniel Koshland’s model

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2
Q

Significance of Km

A

Affinity of enzyme

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3
Q

Mechanism of enzyme inhibitors is described by this model

A

Lineweaver-burk plot

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4
Q

What type of inhibition?

Increased km, Vmax unchanged

A

Competitive Inhibition

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5
Q

Km unchanged, Vmax decreased

A

Noncompetitive inhibition

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6
Q

Competitive inhibitor of HMG-CA

A

Simvastatin

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7
Q

Transfer of Acyl groups and active aldehyde

A

TPP, Lipoic acid, Coenzyme A

“TLC”

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8
Q

Amino transfer

A

Pyridoxal Phosphate

“AMerican Py”

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9
Q

Activation and Transfer of Co2

A

Biocitin

“carbon DI oxide”

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10
Q

Transfer of carbon compounds

A

Tetrahydrofolate

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11
Q

Transfer of Alkyl groups

A

Cobamide (B12)

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12
Q

Synthessized form biopterin

A

Tetrahydrobiopterin

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13
Q

What enzyme catalyzes Phenylalanine hydoxylase, and Tryptophan Hydroxilaze

A

Tetrahydrobiopterin

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14
Q

Deficiency in this enzyme causes PKU

A

Tetrahydrobiopterin, (Phenyl hydroxylase)

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15
Q

What coenzyme is derived from B1

A

Thiamine Pyrophosphate

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16
Q

What ion is required for Thiamine pyrophosphate activity?

A

Mg+

17
Q

3 enzymatic reactions that require TPP

A

Pyruvic acid decarboxylase
Transketolase
Pyruvate dehydrogenase

18
Q

Responsible for oxidative decarboxylation of pyruvate acid

A

Pyruvate dehydrogenase

19
Q

What inhibits biocytin synthesis?

A

Avidin

20
Q

2 enzyme that requires biocytin

A

Acetyl COA carboxylase

Pyruvate carboxylase

21
Q

Tetrahydrofolic acid consists:

A

Subsituted pteridine
P-Aminobenzoic acid (PABA)
glutamic acid

22
Q

Responsible for one-carbon group transfer except CO2

A

Tetrahydrofolic acid

23
Q

Tetrahydrofolic acid inhibitor

A

Methotrexate, sulfonamides

24
Q

Cobamide is derived from?

A

Vit B12 or Cyanocobalamin

25
Q

Tetrapyrole ring with central COBALT atom

A

Cobamide

26
Q

Responsible for isomerization in Cobamide

A

Deoxyadenosylcobalamin

27
Q

What test demonstrates Primary protein structure, protein sequencing

A

Edman’s Reagent

28
Q

“Helix breaker”

A

Prolene

Biochem (8 decks)

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