Enzyme Regulation

Question 1

Covalent modification

Answer 1

Proteins can have several different groups covalently attaches to them which can regulate them

The addition of of a phosphoryl group from a molecule of ATP by a protein kinase to the hydroxyl of serine threonine or tyrosine is the most common examples

Protein phosphorylases can turn on or off the cell

Question 2

Proteolytic cleavage

Answer 2

Many enzymes and other proteins are synthesizes in inactive forms (zymogens) that are activated by cleavage by a protease

Question 3

Association with other polypeptides

Answer 3

Some enzymes have catalytic activity in one polypeptide subunit that is regulated by association with a separate regulatory subunit

Question 4

Allosteric regulation

Answer 4

The modification of active site activity through interactions of molecules with other specific sites on the enzyme called allosteric sites