Enzyme Profile In Liver Diseases Flashcards
Alanine Aminotransferase needs —- as coenzyme
Pyridoxal phosphate
Normal serum level of ALT is
10-30U/L
Very high levels of ALT are seen in
300-1000U/L
Acute hepatitis
Viral or toxic in origin
Both ALT and AST levels are increased but
ALT>AST
Moderate increase of ALT seen in
Chronic liver diseases
Cirrhosis
Hepatitis c
Nonalcoholic steatohepatitis
Nucleotide phosphatase is also known as
5’ nucleotidase
NTP hydrolyses nucleotides to nucleosides at a pH of
7.5
NTP is inhibited by
Nickel ions
But it doesn’t inhibit ALP
NTP is an
Ectoenzyme
NTP serum level is
2-10 IU/L
NTP level is increased in
Hepatitis Biliary obstruction ( highly elevated)
Gamma glutamyl transferase transfers ——-
Gamma glutamyl residues to the substrate
GGT is used in synthesis of
Glutathione
GGT has — isoenzymes
11
GGT is seen in
Liver Kidney Pancreas Intestinal cells Prostate gland
Serum value of GGT
10-30 U/L
Ggt is moderately increased in
Infective hepatitis
Prostate cancer
Ggt is sensitive to detect
Alcohol abusé
Aspartate amino transferase is also called
SGOT
Serum glutamate oxaloacetate transferase
ALT is also called
SGPT
Serum glutamate pyruvate transferase
