Enzyme Inhibition

Question 1

State the characteristics of competitive enzyme?

Answer 1

(Most enzymes)
- Reversible
- Competitor binds at active site
- Molecule looks likeS
- No effect on Vmax
- Increases Km

Question 2

State the characteristics of non-competitive enzyme?

Answer 2

(Allosteric enzymes and Hemoglobin)
- reversible
- binds at Allosteric site
- Molecule does not look like S
- Decreases Vmax
- Kinetics are explained by Hill equation/plot

Question 3

State the characteristics of irreversible or poisons enzymes?

Answer 3

• Heavy metals (Silver, Mercury)
• Nerve gas
• Carbon monoxide (CO)
• Cyanide (CN)