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PSA revision > Enzyme inducers & inhibitors > Flashcards

Enzyme inducers & inhibitors Flashcards

1
Q

Enzyme inducers have what effect on P450 enzyme activity?

A

Increase enzyme activity

Reduce drug concentration

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2
Q

Enzyme inhibitors have what effect on P450 enzyme activity

A

Reduce enzyme activity

Increase drug concentration

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3
Q

What are the most common enzyme inducers?

A

CRAP GPS

Carbemazepine
Rifampicin
Alcohol (chronic excess)
Phenytoin
Barbiturates

Griseofulvin
Phenobarbitone
Sulphonylureas

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4
Q

What are the most common enzyme inhibitors?

A

AODEVICES

Allopurinol
Omeprazole
Disulfiram
Erythromycin
Valproate
Isoniazid
Ciprofloxacin
Ethanol (acute intoxication)
Sulphonamides
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5
Q

Most common enzyme inhibitors

A 
SICKFACES.COM
Sodium valproate
Isoniazid
Cimetidine 
Ketokonazole
Fluconazole
Alcohol (binge drinking)
Chloramphenicol 
Erythromycin
Sulfonamide

Ciprofloxacin
Omeprazole
Metronidazole

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PSA revision (13 decks)

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