enzyme catalysis and coenzymes

Question 1

what is the calculation of free energy change of a reaction

Answer 1

ΔG =ΔH −TΔS

Question 2

Enzymes facilitate reactions by increasing the free energy difference between substrates and products, meaning the equilibrium will favour formation of products true/false

Answer 2

Enzymes do not increase the free energy difference between substrates and products. They only increase the rate at which equilibrium is reached by lowering the activation energy barrier.

Question 3

two basic models describing enzyme substate binding

Answer 3

Lock and Key Model: The enzyme’s active site is a perfect fit for the substrate, and there is no significant change in the enzyme’s structure.
Induced Fit Model: The enzyme’s active site undergoes a conformational change upon substrate binding to better accommodate the substrate.

Question 4

Enzymes facilitate reactions by increasing the free energy difference between substrates and products, meaning the equilibrium will favour formation of products true/false

Answer 4

False.
Enzymes do not increase the free energy difference between substrates and products, nor do they alter the equilibrium of a reaction. The free energy difference (ΔG) between the substrates and products determines the position of equilibrium, and enzymes do not affect this.

Question 5

coenzyme a is important in which type of reaction

Answer 5

acyl group transfer reactions

Question 6

Name two mechanisms of enzyme catalysis

Answer 6

Covalent (nucleophilic) catalysis.
Metal ion catalysis
Electrostatic
Acid-Base Catalysis: Enzymes use acidic or basic groups to stabilize transition states and promote bond formation or breaking.