Environmental Injuries And Anaphylaxis Flashcards

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1
Q

Electrical injuries can cause what things?
Electrical flash and arc burns cause sudden vaporization of metal and deposition of what on the skin?
Electrical arcs also produce what?
In contact burns,tissue damage is more extensive than in which burns or is it tissues manage is more extensive idk check

A

Can cause cardiac and respiratory arrest
•Muscle spasms can cause dislocations or fractures
•Electrical flash and arc burns
•Cause sudden vaporisation of metal and deposition of a thin layer of hot metal on the skin
•May look dramatic because of discolouration of the skin
•Often superficial and heal uneventful
•Electrical arcs produces high temperatures, may cause deep dermal or full-thickness burns
•Contact burns
•Tissue damage more extensive is than visible burns
•Muscle damage may cause myoglobinuria and renal failure

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2
Q

What are the effects of electrical injuries on these conditions :neurological,ophthalmic ,electrocution in pregnancy

A

Neurological :

Coma
•Fits
•Headaches
•Transient paralysis
•Peripheral neuropathy
•Mood disturbances

Ophthalmic : Burns
•Cataracts
•glaucoma

Electrocution in pregnancy:

Major risk for the foetus
•Spontaneous abortion

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3
Q

Lightening burns are superficial often with what characteristic appearance?
Why are the limbs mottled and cold?
What will cause coma in lightening burns?

A

Lightening burns are superficial
•Often with characteristic feathered or fern-like appearance
•Limbs are mottled and cold due to arterial spasm
•Deep muscle damage and myoglobinuria are rare
•Coma
•Result from direct brain injury
•Head injury due to a fall
•Cardiac arrest
•Survivors
•Confused and amnesic for several days

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4
Q

What’s the management of electrical burns and lightening burns

A

Make sure current is turned off before anyone approaches or touches the casualty
•High voltage electricity can arc through the air or pass through the ground
•ABC
•Electrical burns of the mouth and throat may cause oedema and airway obstruction
•Perform CPR if necessary
•Minimise spine movement
•Examine for:
•head, chest, abdominal and skeletal injuries
•Entry/exit burns
•Pulses, sensation

Admit
•Check ECG
•Arrhythmias, conduction defects, ST-elevation, T-wave changes
•Full blood count, Urea and electrolytes and creatine kinase, urine for blood
•Treat for Myoglobinuria to prevent renal failure
•Seek specialist care
•IV Fluids

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5
Q

Most snake bites are non-poisonous
•Commonest cause of poisonous snake bite in tropical Africa: Vipers
•All cases should be observed for at least 6 hours
True or false
How are snakes classified with regards to their fangs
Which people usually get bitten

A
Drunk young men
•Children in endemic areas
•Hobbyists with pet snakes
•Adventure travellers
•Field workers: missionary, military, biologists
•Rural farm workers
Viperidae    : mobile front
•Crotalidae (pit viper): mobile front
•Elapidae:    : fixed front
•Hydrophiidae: fixed front
•Colubridae    : fixed back
•Atractaspididae: sideways
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6
Q

What signs will you see in a patient bitten with veperidae or crotalidae
And signs in elapidae
What are the initial generalized symptoms of snake bite, the local symptoms of snake bite

A

V and C:
Fangs are fixed at the mobile front
Symptoms are hemorrhagic ,necrosis and cardiotoxic

Elapidae:
Fangs fixed at the front
Symptoms are neurotoxic (also sea snake),necrosis

Initial generalised symptoms
➢Fear
➢Dizziness (hyperventilation +++)
➢Nausea and vomiting
➢Malaise
➢Weakness
➢Pain at the bite site
Local symptoms: Local symptoms
➢Wounds by fangs, teeth and misapplied “first aid”
➢Local pain
➢Local ecchymosis & bleeding
➢Local infection & inflammation
➢Local vesicles & necrosis
➢Local lymphangitis
➢Lymphadenopathy
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7
Q

What neurological symptoms and endocrine complications are seen in snake bites

A
Neurological
•paresthesias
•ptosis
•mydriasis
•diplopia and blurred vision
•metallic taste
•Fasciculations
•dysphagia
•slurred speech and
•aphony

Endocrine complications
•Addison (weakness)
•SIADH

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8
Q

What DIC symptoms and renal toxicity symptoms are seen in snake bites

A
Disseminated Intravascular Coagulation
•Bleeding fang marks and venapuncture sites
•Bleeding gums, nose, vagina
•Petechiae
•Retroperitoneal bleeding
•Hematemesis
•Hypophysis
•Adrenals
Renal Toxicity
•Pigment nephropathy (myoglobin, haemoglobin)
•Immune complex nephritis - antivenin
•Acute tubular necrosis
•Cortical necrosis
•Hyperkalaemia
•Shock
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9
Q

What Eye lesion symptoms and muscle toxicity symptoms are seen in snake bites

A
Muscle toxicity
•Especially sea snakes and tiger snakes
•Stiff painful muscles
•Rhabdomyolysis (myotoxins)
•Myoglobinuria
•Hyperkalaemia

Eye lesions
•Spitting cobras: Chemical keratitis with pain and blepharospasms
•Russell’s adder: Chemosis

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10
Q

What treatment should be done in snake bites before going to the hospital

A
Treatment: before hospital
•Diminish fear
•Immobilize limb with a splint
•Compressive elastic bandage (block lymphatic drainage)
•Rinse eyes if relevant

•Transport to the hospital !!

  • Avoid electroshock
  • Avoid arterial tourniquet
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11
Q

What treatment should be done in snake bites in the hospital

A
Evaluate symptoms : dry bite or not?
•Vitals : airway, respiration, BP, pulse, gross bleeding
•Skin swab for venom detection
•IV line
•Intubation set ready
•Wound care
•Limb elevation (swelling)
•Measure limb circumference (repeat)
•BP-monitoring : crystalloids, vasopressors

Investigations
•FBC, Coagulation parameters (INR, APTT, Fibrinogen)
•Dry tube
•Renal function and ionogram
•Glocose, CK, myoglobin
•Urine: blood, myoglobin, pigmented granular casts
•Stools: occult blood
•Plasma-expander: albumin
•Neostigmine 1 mg: blocks acetylcholinesterase
•Atropine 0,6 mg : inhibition muscarine receptors
•Antibiotics
•Tetanus vaccination
•Oxygen
•Crossmatch blood
•Treat myoglobinuria : HCO 3 –, IV mannitol (1 2 g/kg) & loop diuretics
•Treat hyperkalemia (adult)

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12
Q
When will you treat with antivenom 
What will you use to premeditate?
What types of antivenom are there?
How do you give the antivenom?
How do you repeat the antivenom?
When do you repeat the antivenom?
A

Only if venom was injected evidenced by symptoms
•Premedicate with epinephrine and steroids
•Polyvalent or monovalent antivenom
•Dilute, give slow IV over one hour
•Repeat antivenom: 2 vials, diluted after 6, 12 and 18 hours
•Repeat antivenom if
•New bleeding
•Reverting clotting time
•Worsening neurotoxic or cardiovascular effects after 1-2 hours

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13
Q

What are the complications of snake bites

What are the common mistakes done in treating snake bites

A
Abruptio placenta
•Compartment syndrome
•Wound infections
•Volkmann ischemic contracture
•Algoneurodystrophy
•Renal failure
•Endocrine longterm complications

Common mistakes
•Arterial tourniquet
•Cryotherapy, incision of wound
•Incomplete immobilization during transport
•Not thinking of the possibility of snake bite
•Not considering possible worsening of symptoms over time
•Forgetting to control hemostasis repeatedly
•Giving only vasopressors, without IV fluid
•Thinking it is too late to give antivenin
•Too low dosage antivenin, undiluted
•No epinephrine stand by

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14
Q
May carry the rabies virus
•Rabies is a viral infection
•Carried by other animals such as cats, foxes, bats
•Present in the animal’s saliva
True or false 
After dog bites what should be done?
A
Immediate
•Wash site with soap and water
•Irrigation with copious amounts of saline with cetrimide plus and chlorhexidine solution
•Pharmacological treatment
•Flucloxacillin
•Amoxicillin
•Antitetanus prophylaxis
•Rabies immunisation and Rabies vaccine
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15
Q

What is the indication for the use of rabies immunoglobulin and rabies vaccine (condition of the animal stating what happens after observing the animal for ten days and the treatment you’ll give)

A

At time of attack
Dogs condition was Normal
During observation there was No change after
10 days
Vaccination procedure :Do not vaccinate
Immunoglobulin administration :Give first dose

Condition of dog was Normal
During observation Confirmed signs of
rabies after 10 days
Vaccination procedure:Initiate vaccination in patient upon first sign of rabies in animal
Immunoglobulin administration:Give according to
guidelines below(on the next slide)

a.Dog had Strong suspicion
of rabies
During observation :Unconfirmed sign
in animal
Vaccination procedure:Initiate vaccination.
Stop if animal is
normal on day 5
Immunoglobulin administration:Give according to
guidelines.

b.When Rabies is confirmed in the dog with strong suspicion for rabies,
Continue vaccination
regime
Immunoglobulin administration:Give according to
guidelines

Dog has Rabies:
 Immediate
vaccination
Give according to
guidelines
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16
Q

What is the vaccination schedule for rabies with Patients vaccinated within last three years and Patients with no vaccinaton or more than 3 years since vaccination

A

Rabies immunization post exposure (Patients vaccinated within last three years)
Day 0:
Infiltrate wound and around wound with rabies immunoglobulin (10 IU/kg body weight); and
Rabies Immunoglobulin (10 IU/kg body weight) by IM injection;
1 ml Rabies vaccine by IM injection

Day 3 (or any day up to day 7):
1 ml Rabies vaccine by IM injection

Patients with no vaccinaton or more than 3 years since vaccination
Day 0:
Infiltrate wound and around wound with rabies immunoglobulin (10IU/kg body weight); and
Rabies Immunoglobulin (10 IU/kg body weight) by IM injection;
1 ml Rabies vaccine by IM injection

Days 3, 7, 14, 30
1 ml Rabies vaccine by IM injection*

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17
Q

Under clinical features of rabies what’s the incubation period? Symptoms? Prognosis?

A

Incubation period
•3-12 weeks
•Can vary a few days to > 2 years

Symptoms:

Itching, tingling or pain at the site
•Headache
•Fever
•Malaise
•Spreading paralysis
•Episodes of confusion, hallucination and agitation
•Hydrophobia is characteristic
•Dumb paralysis

Prognosis:

Almost always fatal, even with ICU treatment

18
Q

How is dog bite or rabies managed

A

Barrier nurse
•Quiet room
•Minimum staff
•Wear gowns, gloves, eye protection and masks
•Prophylactic immunisation should be offered to those at high risk
•laboratory staff working with rabies virus
•animal handlers
•veterinary surgeons
•wildlife officers likely to be exposed to bites of possibly infected wild animals
•Rabies vaccine 1 ml by IM injection on each of days 0, 7 and 28.

19
Q

Scorpion stings leave a single mark
Are extremely painful

Bee or wasp stings have painful local reactions. Cause generalized uticaria. Death may occur. May cause hypotension and difficulty breathing.
May cause allergic reactions which may lead to anaphylaxis with local pain
True or false

What are the symptoms of scorpion and bee or wasp stings
What are the signs of scorpion stings
What are the signs of wasp or bee stings

A

True

Symptoms:

Painful local reactions
•Swelling

Signs of scorpion stings:
Vomiting 
Abdominal pain
•Excessive salivation
•Sweating
•Rapid respiration
•Single-puncture wound
Signs of wasp or bee stings:
Swelling state
•Urticaria
•Hypotension
•Difficulty in breathing
•Bronchospasm
20
Q

What are the objectives in the treatment of scorpion sting

What is the non pharmacological and pharmacological treatment of scorpion sting

A

Relieve pain
Maintain hydration
Reassure patient

Non pharmacological:

Ice compress on the area
•Detain
•Oral fluids maintenance

Pharmacological treatment

Pain medication: Paracetamol, Aspirin, Ibuprofen, Diclofenac
•1% Lidocaine: 2-5ml for local infiltration to relieve pain

21
Q

What are the objectives in the treatment of bee and wasp stings
What is the non pharmacological and pharmacological treatment of bee and wasp stings

A
  • Relieve pain
  • Manage anaphylaxis
Non pharmacological:
Ice compresses
Detain for observation
•In case of a bee sting, remove the stinger from the skin by scraping. 
Do not pull it out

Pharmacological:

Adrenaline
•Hydrocortisone
•Paracetamol
•Refer with anaphylaxis not responding to treatment

22
Q

What is anaphylaxis
What type of hypersensitivity reaction is anaphylaxis
| How long does it take for it to develop
When does anaphylaxis occur?

A

Generalised immunological condition of sudden onset which develops on exposure to a foreign substance
•Life-threatening
•Rapidly reversible
•Can develop within minutes

Type 1 sensitivity reaction:

Occurs after a previous sensitizing exposure

23
Q

What is the mechanism of action of anaphylaxis

A

IgE immune –mediated activation of basophils and mast cells with subsequent release of prostaglandins, leukotrienes and histamine.

IgE-mediated reaction:
• to a foreign protein (stings, foods)
• or a protein-hapten conjugate (antibiotics) to which the patient has previously been exposed
•Complement mediated
•Human proteins e.g. γ-globulin, blood products
•Unknown
•Aspirin
•Idiopathic
~~~

SEQUENCE OF EVENTS
•Initial exposure to antigen

•Activates T-helper lymphocytes

•Induces plasma cells to produce specific IgE antibody which binds to mast cells and basophils

•Subsequent re-exposure to the antigen

•Antigen binding with IgE on cell surfaces

24
Q

What are the common causes of anaphylaxis

A
Drugs and vaccines
•Antibiotics e.g. penicillin, sulphonamides
•Streptokinase
•Suxamethonium
•Aspirin and NSAIDs
•IV contrast
•Vaccines
•Bee/wasp stings or insect bites
•Foods
•Nuts, Shellfish, strawberries, wheat
• Seafood
•Latex

COMMON CAUSES
•Drugs and vaccines (antibiotics, streptokinase, aspirin, NSAIDS, IV Contrast agents.)
•Hymenoptera, bee/wasp stings
•Foods, nuts ,shellfish, strawberries, wheat
•Latex

25
Q

What are risk factors for severe symptoms
Which people usually have severe features of anaphylaxis
| What are the treatment objectives in the treatment of anaphylaxis

A

CLINICAL FEATURES
•Onset is in minutes/hours
•Speed of onset and severity depends on the amount of the stimulus.
•Patients on beta blockers, IHD and asthmatics usually have severe features.
•Usually two or more systems are involved

Prodromal aura
•Risk factors for severe symptoms
β blockers
History of ischaemic heart disease
•Severe itching
~~~

Treatment objectives

  1. To secure airways, breathing and circulation
  2. To remove the offending cause if possible
  3. To prevent death
26
Q

What are the respiratory and skin signs of anaphylaxis
State five for each signs

A

Respiratory
•Upper airway occlusion
•Swelling of lips, tongues, pharynx and epiglottis
•Lower airway involvement similar to acute asthma

Swelling of lips, tongue, pharynx, and epiglottis may lead to complete upper airway occlusion.

•Dyspnoea, wheeze, chest tightness, hypoxia and hypercapnia

Skin:

Pruritus
•Erythema
•Urticaria
•Angio-oedema

27
Q

What are the cvs and GIt signs of anaphylaxis
State five for each system

A
Cardiovascular
•Hypotension
•Shock
•May be present
•Arrhythmia
•Chest pain
•ECG changes
```Peripheral vasodilation,
•Increase vascular permeability cause plasma leakage from circulation

GI Tract
•Nausea
•Vomiting
•Diarrhoea
•Abdominal cramps
~~~

28
Q

How is anaphylaxi treated acutely
What do you do for patients with shock,airway swelling or respiratory difficulty
What do you do for patients with profound shock or immediately life threatening situations

A
Discontinue further administration of suspected factor
•100 % oxygen (O2)
•Open and maintain airway
•Get senior help
•Urgent intubation
  • In patients with shock, airway swelling, or respiratory difficulty
  • give 0.5mg (0.5mL of 1:1000 solution) adrenaline intramuscular (IM).
  • Repeat after 5min if there is no improvement.
  • In adults treated with an adrenaline autoinjector
  • Give only 50 % of the usual dose of adrenaline to patients taking tricyclic antidepressants, MAOIs, or B –blockers.
  • In profound shock or immediately life-threatening situations:
  • Refer immediately
  • CPR/ALS as necessary, and consider slow IV adrenaline 1:10,000 or 1:100,000 solution. This is recommended only for experienced clinicians who can also obtain immediate IV access.
  • If there is no response to adrenaline, consider glucagon 1–2mg IM/IV every 5min (especially in patients taking B -blockers).
29
Q

What should you give for bronchospams
When do you give IV fluid?
What are second line drugs?
How long should you observe the persons after resolution of all symptoms

A

β2-agonist (eg salbutamol 5mg) nebulized with O2 for bronchospasm, possibly with the addition of nebulized ipratropium bromide 500mcg
•IV fluid if hypotension does not rapidly respond to adrenaline.
•Rapid infusion of 1–2L IV 0.9 % saline may be required, with further infusion according to the clinical state.

  • Second line
  • Antihistamine H1 blockers (e.g. chlorphenamine 10–20mg slow IV) and
  • H2 blockers (e.g. ranitidine 50mg IV)
  • hydrocortisone 100–200mg slow IV
  • Admit/observe after initial treatment. Observe for at least 4-6hrs after resolution of all symptoms
30
Q

How much adrenaline is given in adults
What route is it given
What about in children
How much hydrocortisone is given and what route is it given
How much Promethazine hydrochloride is given and what route is it given

A

Adrenaline, IM,
•Adults
•0.5 ml (500 micrograms) of 1:1000 solution repeated if necessary every 10 minutes and while monitoring blood pressure and pulse
•Children
•0.3 ml (300 micrograms) of 1:1000 solution
•Repeat as for adults.

  • Hydrocortisone, IV,
  • 200 mg 6-8 hourly, to control any late allergic reaction that may occur
  • Promethazine hydrochloride, IM,
  • 25 mg 8-12 hourly
31
Q

What do you treat with if wheeze develops?

A
If wheeze develops give
•Salbutamol, nebulised,
•Adults:
•5 mg 6 hourly
•Children:
•2.5 mg 6 hourly
•Or
•Aminophylline, IV,
•Adults
•250 mg over 20 minutes and repeat after 30 minutes if necessary
•Children
•3-5 mg/kg over 20 minutes as a slow bolus injection or by infusion
•Sodium Chloride, IV, 500 ml-1 litre of 0.9% 4 hourly until fully recovered
32
Q

ISTORY.
18-11-18 @6:30pm.
A 38-year old man with unremarkable past medical history reports to the ED with a history of having been bitten by an unknown animal whilst inspecting his land close to Effia Nkwanta Regional Hospital some few minutes ago.
He describes a feeling of uneasiness and decided to report for evaluation and management.
He was scratching his body and sweating profusely.

CLINICAL VITALS AT TRIAGE 1/2
•SPO2……………..41% ROOM AIR
•RR…………………16 cpm
•HEART RATE………61bpm.
•BLOOD PRESSURE………NON RECORDABLE
•TEMPERATURE………..35.0
•AVPU………..ALERT.

PHYSICAL EXAMINATION
•Unresponsive
•Air entry ……decreased bilaterally
•Breath sounds …….silent
•Added sounds …….nil
•Pulse ….very faint
•Blood pressure ?80/50mmHg

Before the patient could complete his history he started having seizures and became unconscious and unresponsive

What’s your working diagnosis?
How will you manage this patient

A

A working diagnosis of ANAPHYLACTIC SHOCK SECONDARY TO? SCORPION BITE.
• SNAKE BITE.

RESUSCITATION TREATMENT GIVEN
•IV hydrocortisone
•Inj adrenaline
•IV N/S
•High flow O2 @15L/min
•Inj diclofenac

Inj ATS 1500 IU
•IV anti snake venom.
•Elevate the limbs.
•Monitor vitals.

33
Q

What are the risk factors for severe anaphylaxis and poor outcome
State six

A

RISK FACTORS FOR SEVERE
ANAPHYLAXIS & POOR OUTCOME

•Peanut and tree allergy
•Pre-existing cardiovascular disease
•Asthma
•Advanced age
•Pregnancy
•Taking beta-blockers and ACE inhibitors
•Delayed administration of epinephrine

34
Q

State three eye symptoms of anaphylaxis
What is the clinical criteria for dignosis of anaphylaxis

A

Pruritis
•Tearing
•redness

Criteria;
ACUTE ONSET (minutes to hours) with reaction of the skin and /or mucosal tissue in addition to respiratory systems or hypotension .(90% of patients)

  1. Two or more of the following occurring rapidly after exposure to a likely allergen ; skin-mucosal tissue , respiratory symptoms , hypotension, or gastrointestinal symptoms.(10-20% of patients

Hypotension occurring rapidly after exposure to a KNOWN allergen for that patient .(Hypotension may present as faintness or AMS)

35
Q

What is the emergency care of anaphylaxis

A

EMERGENCY DEPARTMENT CARE AND DISPOSITION
1.Resuscitation must begin with airway , breathing and circulation .Patient should be placed on a cardiac monitor with pulse oximetry and IV access secured.
2.Administer supplemental oxygen as indicated by oximetry.
3. Angioedema and respiratory distress should prompt early consideration for intubation .Preparation should also be made for cricothyroidotomy .
4.Limit further exposure

36
Q

What’s the first line therapy for anaphylaxis

A

First line therapy
•Vasopressor for hemodynamic support
•Bronchodilator to relieve wheezing
•Counteracts released mediators to prevent further release.
•Give as soon as possible.
•IM or IV
•Always IM initially in the anterior thigh
•1 :1000 IM 0.3-0.5mg (0.3 -0.5ml) every 5 minutes for up to a total of 3 doses

37
Q

As part of emergency care of anaphylaxis,
What do hypotensive patients with a anaphylaxis require?
If there is no response to adrenaline,what do you do?

A

Hypotensive patients require aggressive fluid resuscitation with NORMAL SALINE 1-2L and a further infusion according to clinical state.

•If there is no response to adrenaline, consider glucagon 1-2mg im/iv every 5 minutes (especially in patients taking beta blockers)

Give salbutamol 5mg nebulised with o2 .

• Ipratropium bromide 500mcg for bronchospasm and

• IV magnesium 2g over 20 -30 minutes

IV Diphenhydramine 50mg.
• H1 blockers (chlorphenamine 10 -20mg slow iv)
•H2 blockers (ranitidine50 mg iv)
•Iv hydrocortisone 100-200mg slow ,may reduce the severity and duration of symptoms or
•Iv methylprednisolone 125 mg

Admit/observe after initial treatment.
•Prolonged and biphasic responses may occur.(20%)
•Observe for at least 4-6 hours after all symptoms have settled.
•Discharge all patients on an antihistamine and a short course of prednisolone.
•Oral prednisolone 60mg.

38
Q

State the specific investigation that can be done to confirm for anaphylaxis retrospectively

A

Clinical diagnosis
•The specific investigation which may help confirm the diagnosis RETROSPECTIVELY is measurement of the MAST CELL TRYPTASE.
•Mast cell degranulation leads to increase levels of TRYPTASE.
•Useful for follow up in suspected cases but will not alter ED management.
•Ideally 3 samples are taken .
•The initial sample should be taken as soon as possible but should not delay resuscitation .
•The second , 1-2 hours after the start of symptoms.
•The third, after 24 hours.

39
Q

PITFALLS IN ANAPHYLAXIS MANAGEMENT

•Failure to recognize symptoms of anaphylaxis.
•Underestimating the severity of laryngeal edema and failure to secure the airwave early.
•Reluctance to administer epinephrine early in course of illness.
•Forgetting to remove the allergen; eg, the IV drip of penicillin or bee stinger.
•Lack of appropriate patient education.
•Failure to prescribe an epinephrine auto-injector prior to discharge.
True or false

An 18 year old woman is brought to the ED with suspected anaphylaxis. Which of the following most suggest anaphylaxis rather than a simple allergic reaction

•A Itching
•B Watery eyes
•C Blood pressure of 80/40mmhg
•D Hives
•E Anxiety

Which of the ff management options is the greatest determinant of patient outcome in anaphylaxis?
A) Timely administration of steroids
B) Administration of diphenhydramine
C) Early identification of the allergen.
D) Early administration of epinephrine
E ) Aggressive resuscitation with intravenous fluids

A
40
Q

6 year old girl with a known peanut allergy is brought to the ED by ambulance after accidentally eating a cookie made with peanut butter at a school party. She is wheezing with hives. Which of the ff should be the first intervention?

A) Endotracheal intubation
B) Normal saline 20 cc/kg iv
C) Examination of the skin.
D) Epinephrine 0.15mg IM
E ) Nebulise albuterol.

32-year old man collapses in the emergency room after being brought by paramedics. He was stung by a bee and known to be highly allergic. He appears cyanotic and had extreme stridor in the ambulance. Severe laryngeal edema is notable. Which of the following is the best treatment?

A.Nebulized albuterol, H1 and H2 antagonist, Corticosteroids, and crystalloids
B.Subcutaneous epinephrine, H1 and H2 antagonist, and corticosteroids
C.Rapid sequence intubation, subcutaneous epinephrine, and corticosteroids
D.Intramuscular epinephrine, rapid sequence intubation, and corticosteroids
E.Intravenous epinephrine, rapid sequence intubation with preparation for a surgical airway, corticosteroids, nebulized albuterol, HI and H2 antagonists

A