Entire Course Terms Flashcards
gastrinoma
Zollinger-Ellison syndrome: A rare disorder caused by a tumor called a gastrinoma, most often occurring in the pancreas. The tumor secretes the hormone gastrin, which causes increased production of gastric acid leading to severe recurrent ulcers of the esophagus, stomach, and the upper portions of the small intestine (the duodenum and jejunum).
Gastrinomas resulting in the Zollinger-Ellison’s syndrome are not limited to the pancreas but may also occur in the stomach, duodenum, spleen and lymph nodes.
root of a word
primary lexical unit, carries the most significant aspects of semantic content and cannot be reduced into smaller parts. The root is a unit of meaning (morpheme)
epi-
above; on top
gastr/o
stomach
-ic
belongs to; pertains to
prefix
initial portion of some object or term with a distinct and reused meaning that modifies the meaning of the whole object. To prefix is to attach before.
hyper-
above normal; super
-ism
condition
suffix
follows the morphemes, modifies the root
tonsil
lymphatic mass in the oropharynx
-tomy
ablation; removal; cutting off
-logy
suffix
a-
no
-chondro-
cartilage
-plasia
development
achondroplasia
Achondroplasia is a genetic (inherited) condition that results in abnormally short stature and is the most common cause of short stature with disproportionately short limbs. The average height of an adult with achondroplasia is 131 cm (52 inches, or 4 foot 4 inches) in males and 124 cm (49 inches, or 4 foot 1 inch) in females.
Although achondroplasia literally means “without cartilage formation,” the defect in achondroplasia is not in forming cartilage but in converting it to bone, particularly in the long bones.
arrhythmia
An abnormal heart rhythm.
atheros
artery
-sclerosis
hardening
atherosclerosis
disease of major arteries with the formation of the atheroma or plaque
atheroma
A fatty deposit in the inner lining (intima) of an artery, resulting from atherosclerosis. Also called an atherosclerotic plaque, an arterial plaque, or a plaque.
glucagonoma
neuroendocrine tumor with nearly exclusive pancreatic localization. The tumor’s presence is characterized by glucagon overproduction, weight loss, diabetes mellitus, hypoaminoacidemia, normochromic and normocytic anemia, and necrolytic migratory erythema (NME), which is the most characteristic clinical sign (as opposed to symptom) of this pathology.
Lipoma
A benign tumor of adipocytes (fat cells). Common in the skin and are found anywhere on the body. They may be surgically removed for cosmetic reasons.
astrocytoma
A tumor that begins in the brain or spinal cord in small, star-shaped cells
astrocyte
cell of the nervous system
arteriosclerosis
Hardening and thickening of the walls of the arteries.
diverticulosis
condition of having diverticula, small outpouchings from the large intestine, the colon. (One outpouching is a diverticulum; two or more are diverticula).
diverticulitis
Inflammation of the diverticula (small outpouchings) along the wall of the colon, the large intestine.
-osis
condition
-itis
infection or inflammation
pneumology
The science which treats of the lungs
arthro-
joint
-my-
muscle
-algia
pain
gastro-
stomach
-entero-
small intestine
-chol-
colon
laryngitis
inflammation of the larynx
electro-encephalo-graph (EEG)
An instrument that measures electrical potentials on the scalp and generates a record of the electrical activity of the brain
electro-cardio-gram (EKG/ECG)
a tracing of the electric currents that initiate the heartbeat, used to diagnose possible heart disorders
cysto-
bladder
scopy
view
-cele
hernia
inguinal hernia
condition in which part of the intestine bulges through a weak area in muscles in the abdomen
-cise, -cision
cut, cutting
phimosis
inability to retract the distal foreskin over the glans penis
pathologic phimosis
defines an inability to retract the foreskin after it was previously retractible or after puberty, usually secondary to distal scarring of the foreskin.
paraphimosis
entrapment of a retracted foreskin behind the coronal sulcus. A disease of uncircumcised or partially circumcised males.
omphalocele
congenital malformation in which variable amounts of abdominal contents protrude into the base of the umbilical cord
Hiatal hernia
occurs when the stomach protrudes into the chest cavity
mast-
breast
gynecomastia
the development of abnormally large mammary glands in males resulting in breast enlargement
gigantomastia
hypertrophy of breast, or macromastia, is a rare connective tissue disorder. It has benn qualified as enlargement of the breast exceeding 600 grams (21 oz), causing discomfort and stretching of the overlaying skin leading to ulceration
lumpectomy
removal of the lump, mass, tumor
pathogenesis
the mechanism by which a certain etiological factor causes disease/The development of a disease and the chain of events leading to that disease.
etiology
study of causation
angio-
vessel
neo
new
-genesis
generate
-emia
blood
-glyc-
sugar
-glic
sugar
hypotrophy
progressive degeneration of an organ or tissue caused by loss of cells
hypertrophy
nontumorous enlargement of an organ or a tissue as a result of an increase in the size rather than the number of constituent cells
anatomy
study of the structure of living beings
meta-
change
-eal, -iac, -ose
pertaining to
-ism
process
-plasm
formation
-somes
bodies
cancer
immature cell that reproduces too fast because of damaged DNA from a carcinogen or spontaneous mutation. Failure of immune system and natural killer cells to kill cancer cells.
Erythrocyte
A cell in the blood of vertebrates that transports oxygen and carbon dioxide to and from the tissues. Disk-shaped and biconcave, contains hemoglobin, lacks a nucleus.
Erythropoietin EPO
Hormone produced by the kidneys when there is a drop of O2 in the blood
Hypoxia
low level of O2 in a tissue
Ischemia
restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism (to keep tissue alive).
isch-
restriction
hema/haema
blood
spherocytosis
the disease is characterized by abnormal red blood cell membrane proteins, which cause the cell to assume a spherical shape rather than the usual “doughnut with a filled in center” shape
Anemia
deficiency in erythrocytes or hemoglobin
Aplastic anemia
The capacity of the bone marrow to generate red blood cells is defective. Caused by bone marrow disease or exposure to toxic agents, such as radiation, chemicals, or drugs. AKA pancytopenia
-plasty
formation or plastic repair of.
hemolytic anemia
Caused by the lysis of RBCs, as in response to certain toxic or infectious agents and in certain inherited blood disorders. chronic forms of this disease that occurs almost exclusively in people of african descent and characterized by sickle-shaped RBCs caused by homozygous inheritance of Hb S.
lysis
breaking down of a cell, often by viral, enzymic, or osmotic mechanisms that compromise its integrity. A fluid containing the contents of lysed cells is called a lysate.
Glucose-6-Phosphate Dehydrogenase Deficiency
Hereditary condition in which red blood cells break down when the body is exposed to certain drugs or the stress of infection. > 400 variants. inherited as an x-linked disorder, affects 400 million ppl worldwide. Confers protection against malaria, which probably accounts for its high gene frequency.
Hemoglobinopathies
group of disorders passed down through families (inherited) in which there is abnormal production or structure of the hemoglobin molecule. Such disorders include hemoglobin C disease, hemoglobin S-C disease, sickle cell anemia, and various types of thalassemia.
sickle cell disease, sickle cell trait
homozygous (SS), heterozygous
Sickle cell anemia
caused by autosomal recessive gene. body makes sickle-shaped red blood cells. “Sickle-shaped” means that the red blood cells are shaped like a crescent. Sickle cells contain abnormal hemoglobin called sickle hemoglobin or hemoglobin S. Sickle hemoglobin causes the cells to develop a sickle, or crescent, shape.
Sickle cells are stiff and sticky. They tend to block blood flow in the blood vessels of the limbs and organs. Blocked blood flow can cause pain and organ damage. It can also raise the risk for infection.
allele
any one of a number of viable DNA codings occupying a given locus on a chromosome
autosome
a non-sex chromosome. An ordinary paired, of chromosome that is the same in both sexes of a species. In humans there are 22.
An allele that causes a phenotype that is only seen in a homozygous genotype (an organism that has 2 copies of the same allele) and never in a heterozygous genotype
recessive gene
Dominant
allele causes a phenotype that is seen in a heterozygous genotype. Many traits are determined by pairs of complementary genes, each inherited from a single parent.
phenotype
either total physical appearance and constitution or a specific manifestation of a trait, such as size, eye color, or behavior that varies between individuals. Determined by genotype and environmental factors.
specific genetic makeup (the specific genome) of an individual, in the form of DNA
genotype
homozygous
2 identical alleles or DNA sequences at one locus
heterozygous
2 different alleles at one locus
hemizygous
presence of only a single copy of the gene in an otherwise diploid organism
zygote
cell that is the result of fertilization. Usually 2 haploid cells (sperm and ovum) merge into a single diploid cell.
labyrinthitis
inflammation of the inner ear (labyrinth). Characterized by dizziness, nausea, and visual disturbances. AKA otitis interna
iatrogenic
to be induced inadvertently by a physician, surgeon, or medical procedure. Condition caused by medicine.
orthopnea
difficulty breathing or shortness of breath that occurs when lying down and is relieved when turning to an upright position.
ortho-
Prefix meaning straight or erect
pnea
breath, respiration
lumbalgia, lumbago
lower back pain, between pelvis and posterior ribs. Steady pain, usually caused by stress - lack of O2 in muscles.
colic pain
form of pain which starts and stops abruptly. It occurs due to muscular contractions of a hollow tube (colon, ureter, gall bladder, etc.) in attempt to relieve the obstruction by forcing content out. It may be accompanied by vomiting and sweating.
Echolalia
the often pathological repetition of what is said by other people as if echoing them. 2 forms - immediate and delayed
-laleos, -lalein, -lalia
talkative, chatter, speech
demyelination
loss of myelin on axons
idiopathic
arising spontaneously or from an obscure or unknown cause
angioneogenesis
the process by which a tumor attracts blood vessels to nourish itself and sustain its existence.
idio-
peculiar to a substance or organism.
Dr. Folkman
In 1971, he reported in the New England Journal of Medicine that all cancer tumors are angiogenesis-dependent. If a tumor could be stopped from growing its own blood supply, he surmised, it would wither and die.
Ivan Illich
He introduced to a wider public the notion of iatrogenic disease which had been scientifically established a century earlier by British nurse Florence Nightingale (1820–1910). Others have since voiced similar views, but none so trenchantly.
transgenic
Of, relating to, or being an organism whose genome has been altered by the transfer of a gene or genes from another species or breed
sacrococcygeal
Of, relating to, or affecting the sacrum and coccyx
thrombophlebitis
Inflammation of a vein caused by or associated with the formation of a blood clot.
galactogogue
a substance that promotes lactation in humans and other animals. It may be synthetic, plant-derived, or endogenous
microcephaly
a head circumference (HC) more than 2 standard deviation below the mean for age and gender
pachyonychia
autosomal dominant skin disorder. Symptoms: excess keratin in nail beds and thickening of the nails, Hyperkeratosis on hands and feet, Oral lesions that look like thick white plaques
urticaria
commonly referred to as hives, is a kind of skin rash notable for pale red, raised, itchy bumps. Hives might also cause a burning or stinging sensation.[2] Hives are frequently caused by allergic reactions; however, there are many nonallergic causes
thrombo-
blood clot
-phleba
vein
galacto-
milk
-gogue
to lead or bring
cephale
head
pachy
thick
onych
nail
urtica
family of plants with nettles
synarthrosis
a rigid joint formed by the union of 2 bones and connected by fibrous tissue
macrophage
any of the large phagocytic cells of the reticuloendothelial system
reticuloendothelial system / mononuclear phagocyte system (MPS)
part of the immune system that consists of the phagocytic cells located in reticular connective tissue. The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. The Kupffer cells of the liver and tissue histiocytes are also part of this.
pseudopods
temporary projections of eukaryotic cells or unicellular protists
cytokine
small signaling molecules used for cell signaling. Can be classified as proteins, peptides, or glycoproteins; the term encompasses a large and diverse family of regulators produced throughout the body by cells of diverse embryological origin
phagocyte
the cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells
phagocytosis
literally “cell-eating”, is a form of endocytosis wherein large particles are enveloped by the cell membrane of a larger cell and internalized to form a phagosome or food vacuole
neutrophil
n. most abundant type of white blood cell in mammals and form an essential part of the innate immune system. make up 50-70% of circulating white blood cells. type of phagocyte and are normally found in the blood stream. During the beginning (acute) phase of inflammation, particularly as a result of bacterial infection, environmental exposure, and some cancers, neutrophils are one of the first-responders of inflammatory cells to migrate towards the site of inflammation
adj. not stained strongly or definitely by either acid or basic dyes bur stained readily by neutral dyes.
eosinophil
are white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells, they also control mechanisms associated with allergy and asthma. They release histamine during an allergic reaction. Contain cytoplasmic granules that are easily stained by eosin or other acid dyes.
basophil
least common of the granulocytes, representing about 0.01% to 0.3% of circulating white blood cells. Granules stain readily with basic dyes. They appear in many specific kinds of inflammatory reactions, particularly those that cause allergic symptoms, store histamine.
monocyte
a large, circulating, phagocytic WBC, having a single well-defined nucleus and very fine granulation in the cytoplasm. Constitute from 3 - 8% of the WBCs in humans. Play multiple roles in immune function. Such roles include: (1) replenish resident macrophages and dendritic cells under normal states, and (2) in response to inflammation signals, they can move quickly (approx. 8–12 hours) to sites of infection in the tissues and divide/differentiate into macrophages and dendritic cells to elicit an immune response. Half of them are stored in the spleen.
lymphocyte
any of the nearly colorless cells found in the blood, lymph, and lymphoid tissues, constituting approximately 25% of the WBCs and including B cells, which function in humoral immunity, and T cells, which function in cellular immunity. can be divided into large and small. Large granular ones include natural killer cells (NK cells). Small ones consist of T cells and B cells. Fight viral infections.
platelets / thrombocytes
cell fragments circulating in the blood that are involved in the cellular mechanisms of primary hemostasis leading to the formation of blood clots. No DNA or nucleus.
pulmonary embolism
blockage of the pulmonary artery by foreign matter or by a blood clot
-penia
suffix, scarcity, a few, lack of
leukopenia
scarcity of WBCs, places individuals at increased risk of infection.
neutropenia
a granulocyte disorder characterized by an abnormally low number of neutrophils