Enterovirus

Question 1

Characteristics of picornaviridae

Answer 1

1. Small
2. Non-enveloped
3. ssRNA (+)

Question 2

features of enteroviruses

Answer 2

1. stable
   - insensitive to detergents
   - survive cold and hot temps
2. Replicate in GIT
3. Warm Moist Environments

Question 3

Types of Viruses under ‘enterovirus’

Answer 3

1. Poliovirus
2. Coxsackie Virus
   - Coxsackie A
   - Coxsackie B
3. Echovirus (Enteric Cytopathic Human Orphan)
4. Rhinovirus

Question 4

Clinical Presentation of Enteroviruses

Answer 4

1. Upper Respiratory Tract Infection (normal)
2. Hepatitis (complication)
3. Meningitis, Encephalitis, Paralysis (complication)
4. Myocarditis, Pericarditis (complication)
5. Rash, Herpangina, HFMD (normal)

Question 5

virus isolation for enterovirus

Answer 5

not useful bc slow, better for surveillance as virus takes few days to weeks to replicate

Question 6

difference between coxsackie A and B

Answer 6

B and echoviruses can be readilky grown in cell culture from throat swabs, feces, rectal swabs, CSF

A cannot be isolated easily in cell culture

A mainly epithelial infection (herpangina, HFMD) vs B muscular (myocarditis)

Question 7

diagnosis of enterovirus

Answer 7

RT-PCR
Genetic sequencing for typing

Question 8

enterovirus A71 causes?

Answer 8

Childhood exanthem
HFMD indistinguishable from CA16

might lead to CNS infection (encephalitis)

Question 9

enterovirus D68 causes

Answer 9

Respiratory Disease Outbreak

Question 10

what viruses cause HFMD? which causes more severe?

Answer 10

CA16, CA6, CA24, EV71. EV71