Entamoeba histolytica

Question 1

Treatment

Answer 1

metronidazole
tinidazole
iodoquinol/paromomycin (asymptomatic cyst)

Question 2

Pathogenesis

Answer 2

cysts ingestion -> fecal-oral transmission
no animal reservoir

Question 3

Life cycle

Answer 3

trophozoites (colonic epit) -> secrete enzymes (local necrosis & inflammation) -> lesion (muscular layer) -> destry intestinal epit. -> submucosa -> invade portal circulation (liver systemic disease) -> intestinal disease (colon); amebic dysentry -> spread to LIVER, BRAIN, LUNG (extraintestinal disease)

Question 4

Properties

Answer 4

amebic dysentry
liver abscess

Question 5

Life cycle (important)

Answer 5

trphozoite
non motile cyst

Question 6

Mature infective cyst

Answer 6

4 nuclei excystation divides to trophozoites

Question 7

Mature trophozoites

Answer 7

1 nucleus, even peripheral chromatin, prominent central karyosome