ENT flashcards
at risk of second primary cancerization
entire upper aerodigestive tract
high risk pts for head and neck cancer
tabacco and alocohol users
leukoplakia
white plaque cannot be easily scraped off without bleeding. 5% chance of becoming cancerous
erythroplasia
More severe than leukoplakia. 75% chance of becoming cancerous
stridor
noisy breathing ingeneral. Oftenassociated with croup.
2 most common premalignant signs in the oropharynx
erythroplakia and leukoplakia
oral lesion persisting more than 3 weeks…
needs a biopsy
Most common type of cancer of the oropharynx.
squamous cell carcinoma
most common lip cancer located..
lower lip – tobacco, alcohol, chronic sun exposure
cancer of the upper lip is most commonly…
BCCA – basal cell carcinoma
neck mass referral if longer than…
3 weeks
adenoid cystic carcinoma
bucal mucosa
HPV associated oropharyngeal cancer
has gone up. 50% of SCCA oropharynx is HPV +
considered non-smoker
<10 pack year
HPV basaloid squamous cell ca
younger pts, with cystic neck mass, low tobacco and OH utilization.
HPV high risk
more than 7 sexual partners, more than 4 oro-genital sex partners. Associated with open mouth kissing.
How come HPV?
dysregulation of molecules. E6 decreases P53 activity. E7 decreases RB activity
HPV possitive cancers have an ______ survival rate when compared with other oropharyngeal cancers.
increased
what structure are you most likely to injure when operating on parotid gland?
VII – facial
Stensen’s duct …
pierces buccinator at the 2nd molar
parotid, submandibular, and sublingual glands
parotid has the highest proportion of neoplasms, minor salivary glads have highest proportions of malignancy.
Bicellular theory
neoplastic development within the salivary glands originates from basal cells seen in excretory and intercalated ducts.
excretory duct neoplasms
SCCA and mucopeidermoid carcinoma.
intercalated duct neoplasms
pleomorphic adenoma, warthin’s tumor, oncocytoma, acinic cell carcinoma, and adenoid cystic carcinoma.
Multicellular theory
neoplasm development is from DIFFERENTIATED cells within the salivary gland unit.
striated duct neoplasms
oncocytic tumors
acinar cell neoplasms
acinic cell carcinoms
parotid tumors
mostly painless, if painful – pain, facial nerve paralysis or numbness, trismus.
pleomorphic adenoma
benign mixed tumor, parotid, 30s-50s, women, slow growing, painless, firm. Solitary, tail of superficial lobe – no effect on CN VII. Well encapsulated – demarcated. Chondroid stroma.
Warthins tumor
2nd most common benign parotid neoplasm. Papillary cystadenoma lymphomatosum. Males 30+. Only neoplasm associated with tobacco and EtOH. Aspirate straw colored fluid. Cysts with shaggy irregular lining. Pathognomonic features – epithelial cells forming papillary projections into cystic spaces in a backround of lymphoid stroma.