Endrocrinolgy of Excercise and Stress Flashcards
What are the effects of norepinephrine and epinephrine on insulin?
Inhibits the release of insulin so that GLUT-4 cannot uptake glucose and GLUT-1 in muscle cells can take glucose still
Effects of muscle contraction and glycogenolysis?
Contraction leads to increased Ca ions; Ca ions bind to calmodulin which then directly activates phosphorylase kinase increasing glycogen degradation
What occurs to the RAAS axis during exercise?
Increase in aldosterone renin and ANP at 25-40% VO2 max
A-II and ADH increase at 60-80% VO2 max
What occurs to the HPA axis with exercise?
During stress of exercise: IL-6 increases-> increase in CRH and AVP -> ACTH
What does the increase of CRH, cortisol and beta-endorphin cause in exercise?
CRH inhibits GnRH and therefore LH and FSH
What does IL-6 cause?
Stimulation of CRH and ADH secretion leading to cortisol release
What is the female athlete triad that leads to exercise induced amenorrhea?
Eating disorder
Hypothalamic amenorrhea
Osteoporosis
What does extensive exercise cause in males?
Suppression of LH and testosterone levels
What is the term for healthy homeostasis?
Eustasis
What is term for different homeostasis?
Allostasis
What is the term for defective homeostasis?
Cacostasis
What part of the brain does the stress system activate?
Amygdala: Fear
Hippocampus: Anger and memory
What is the locus ceruleus?
Adrenal gland of the CNS
Where is the locus ceruleus located?
Dorsal wall of the pons
What does the locus ceruleus produce?
NE in the brain
