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Bacteriology > Endotoxin Vs Exotoxin > Flashcards

Endotoxin Vs Exotoxin Flashcards

0
Q

Component of the cell wall of gram negative bacteria only and released after cell death

A

Endotoxin

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1
Q

Produced by live bacteria, both gram positive and gram negative

A

Exotoxin

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2
Q

Often spontaneously diffusable

A

Exotoxin

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3
Q

Cell bound as part of cell wall

A

Endotoxin

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4
Q

Labile to heat, chemicals, and storage

A

Exotoxin

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5
Q

Very stable to heat, chemicals, storage

A

Endotoxin

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6
Q

Made of proteins and polypeptides

A

Exotoxin

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7
Q

Lipopolysaccharide complex containing lipid A (toxic component), core polysaccharides and O side chains

A

Endotoxin

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8
Q

Potent toxins (lethal in minute amount), with distinct structure and specific activity depending on the bacteria species of origin

A

Exotoxin

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9
Q

Moderate toxins (variable between species of bacteria and species of animal), similar structure regardless of bacterial species of origin

A

Endotoxin

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10
Q

Not pyrogenic

A

Exotoxin

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11
Q

Potent pyrogenic

A

Endotoxin

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12
Q

Highly antigenic, often readily converted to toxoids which induce neutralizing antibodies

A

Exotoxin

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13
Q

Weakly antigenic, not amenable to toxoid production and questionable efficacy of O side chain mutants. Neutralizing antibodies not associated to natural exposure.

A

Endotoxin

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14
Q

Synthesis determined extrachromosomally

A

Exotoxin

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15
Q

Encoded in chromosome

A

Endotoxin

16
Q

Effects - cell membrane damage and subsequent lysis of cells through :

  • enzymatic digestion
  • formation of pores
  • phagocytes (& RBCs) are often a target of these toxins and therefore they affect a major defense mechanism of the host
A

Exotoxin

17
Q

Effects : interaction with the following :

  • macrophages
  • neutrophils
  • platelets
  • B Lymphocytes
A

Endotoxin

18
Q

Effects : Interference with protein synthesis

A

Exotoxin

19
Q

Effects : Release of IL-1 (leading to fever), TNF and IL-6 etc

A

Endotoxin

20
Q

Effects : Elevation of cAMP concentrations

A

Exotoxin

21
Q

Effects : Activation of inflammatory cascade which may lead to widespread tissue destruction

A

Endotoxin

22
Q

Effects : Disruption of functions related to nervous tissues

A

Exotoxin

23
Q

Effects : degradation of components of interstitial tissue; collagen, elastin, etc

A

Exotoxin

24
Q

Effects : act as super antigens

A

Exotoxin

Bacteriology (3 decks)

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