Endotoxin Vs Exotoxin

Question 0

Component of the cell wall of gram negative bacteria only and released after cell death

Answer 0

Endotoxin

Question 1

Produced by live bacteria, both gram positive and gram negative

Answer 1

Exotoxin

Question 2

Often spontaneously diffusable

Answer 2

Exotoxin

Question 3

Cell bound as part of cell wall

Answer 3

Endotoxin

Question 4

Labile to heat, chemicals, and storage

Answer 4

Exotoxin

Question 5

Very stable to heat, chemicals, storage

Answer 5

Endotoxin

Question 6

Made of proteins and polypeptides

Answer 6

Exotoxin

Question 7

Lipopolysaccharide complex containing lipid A (toxic component), core polysaccharides and O side chains

Answer 7

Endotoxin

Question 8

Potent toxins (lethal in minute amount), with distinct structure and specific activity depending on the bacteria species of origin

Answer 8

Exotoxin

Question 9

Moderate toxins (variable between species of bacteria and species of animal), similar structure regardless of bacterial species of origin

Answer 9

Endotoxin

Question 10

Not pyrogenic

Answer 10

Exotoxin

Question 11

Potent pyrogenic

Answer 11

Endotoxin

Question 12

Highly antigenic, often readily converted to toxoids which induce neutralizing antibodies

Answer 12

Exotoxin

Question 13

Weakly antigenic, not amenable to toxoid production and questionable efficacy of O side chain mutants. Neutralizing antibodies not associated to natural exposure.

Answer 13

Endotoxin

Question 14

Synthesis determined extrachromosomally

Answer 14

Exotoxin

Question 15

Encoded in chromosome

Answer 15

Endotoxin

Question 16

Effects - cell membrane damage and subsequent lysis of cells through :

• enzymatic digestion
• formation of pores
• phagocytes (& RBCs) are often a target of these toxins and therefore they affect a major defense mechanism of the host

Answer 16

Exotoxin

Question 17

Effects : interaction with the following :

• macrophages
• neutrophils
• platelets
• B Lymphocytes

Answer 17

Endotoxin

Question 18

Effects : Interference with protein synthesis

Answer 18

Exotoxin

Question 19

Effects : Release of IL-1 (leading to fever), TNF and IL-6 etc

Answer 19

Endotoxin

Question 20

Effects : Elevation of cAMP concentrations

Answer 20

Exotoxin

Question 21

Effects : Activation of inflammatory cascade which may lead to widespread tissue destruction

Answer 21

Endotoxin

Question 22

Effects : Disruption of functions related to nervous tissues

Answer 22

Exotoxin

Question 23

Effects : degradation of components of interstitial tissue; collagen, elastin, etc

Answer 23

Exotoxin

Question 24

Effects : act as super antigens

Answer 24

Exotoxin