Endometriosis, Infertility, Cysts, Sexual Assault, Urinary Incontinence Flashcards
24 yo nulligravid f w. 18 mo hx of painful intercourse, difficulty defacating, and dysmenorrhea - sx are cyclical and occur w. menses - her menses are regular but very heavy - she has no hx of STI and is monogamous w. her husband
endometriosis
2 PE findings of endometriosis
-retroverted uterus w. nodularity
-ttp of uterosacral ligaments and cul-de-sac
endometriosis is a condition in which ectopic endometrial tissue implants are found in extrauterine sites, mc the _ (4)
ovaries
fallopian tubes
cul-de-sac
uterosacral ligaments
3 d’s of endometriosis
dyspareunia
dyschezia
dysmenorrhea
also infertility
20% of women w. endometriosis will have what sx
chronic stomach pain
definitive dx for endometriosis is _,
which is confirmed w. _
laparoscopy confirmed w. bx
t/f: US, barium enema, IV urography, CT, and MRI are all acceptable for dx of endometriosis
f!
they are not specific or adequate
6 tx options for endometriosis
NSAIDs
OCPs
danazol
depo-provera
GnRH agonists
surgery
first line tx for endometriosis
OCP
moa for combined OCP and progesterone analogs in endometriosis tx
combined OCP: ovarian suppression
progesterone analogs: inhibit growth of endometrium
name 2 progesterone analogs
medroxyprogesterone
levonorgestresl
how do GnRH antagonists tx endometriosis
pituitary GnRH suppressed -> decreased estrogen
moa for donazol
steroid -> inhibits mid-cycle FSH/LH surge
2 surgical options for endometriosis
-lapraoscopic ectopic endometrial tissue removal
-hysterectomy
definition of infertility
inability to conceive w.in 12 mo of unprotected intercourse
primary infertility is defined as infertility in the absence of
previous pregnancy
secondary infertility is defined as infertility after a
previous pregnancy
fertility is _% female
and _% male
female: 65%
male: 20-40%
unknown: 15%
mc cause of infertility
anovulation
4 causes of infertility
anovulation
tubal dz
male factor
idiopathic/multifactorial
steps in work up of infertility
- detailed hx - type of coitus, when, where, how often
- ovulation tracking
- semen analysis
- labs
- hysterosalpingogram vs laparoscopy
variables in ovulation tracking
-menstrual diary
-luteal phase progesterone level
-basal body temp
if progesterone level is < _ on day 21 of the luteal phase, you know your pt did not ovulate
3 ng/ml
body temp indication of female infertility
no mid-cycle basal body temp increase
4 labs useful in dx of female infertility
TSH
prolactin
LH
FSH
3 meds used in tx of female infertility
-clomiphene citrate
-metformin
-bromocriptine
moa for clomiphene citrate
hyperstimulates ovulation
when is metformin used for infertility
if PCOS is the cause
increases ovulation
when is bromocriptine used to tx female infertility
hyperprolactinemia
39 yo AA f w. hx abnormally heavy menstrual bleeding and increased pelvic pressure - no pain - enlarged uterus
leiomyoma
PE finding of leiomyoma
enlarged uterus w. asymmetric contours
benign smooth muscle cell tumors
leiomyoma
6 sx of leiomyoma
polymenorrhea
menorrhagia
intermenstrual bleeding/metorrhagia
pelvic presure
increased abd girth
uterine mass
what pt pop do you think of when you see leiomyoma
AA
fam hx
3 types of leiomyoma
subserosal
intramural
submucosal
what type of leiomyoma projects into the pelvis and may be pedunculated
subserosal
what type of leiomyoma is contained w.in the uterine wall
intramural
what type of leiomyoma projects into the uterine cavity
submucosal
dx for leiomyoma
US
MRI if uterine mass
symptomatic tx for leiomyoma
NSAIDs
OCPs
danazol
leuprolide
what medication shrinks leiomyomas pre operatively
leuprolide
definitive tx for leiomyoma
myomectomy
endometrial ablation
hysterectomy