Endometriosis - AUD Lecture

Question 1

What is endometriosis

Answer 1

Pelvic inflammatory condition associated with growth of endometrial tissue found outside the uterus
symptoms can be asymptomatic to severe symptoms
Most common symptoms include - dysmenorrhea ( pain associated with period), infertility, dyspareunia

Question 2

Risk factors

Answer 2

• over age of 20
• weight loss attmepts
• depression and anxiety
• heavy menses
• menarche before age of 12
• nulliparity
• smoking
  -family history

Question 3

Symptoms

Answer 3

Dysmenorrhea
chronic pelvic pain
infertility
bloating
heavy bleeding
has many Nonspecific symptoms which can lead in the delay of diagnosis for endometriosis

Question 4

Pathophysiology

Answer 4

Not fully understood
but some support that its retrograde menstrual flow

Question 5

Non-pharmacologic treatment for endometriosis

Answer 5

Exercise
acupuncture
massage
CBT
Surgery

Question 6

Medication management

Answer 6

First line - NSAIDS, CHCs, Progestins
Second line - GnRH agonist or antagonists, and danazol
Third line - Aromatase inhibitor

Question 7

Danazol (second-line treatment)

Answer 7

MOA - androgen that suppresses FSH and LH production
SE - weight gain, acne, hirsutism, lipid abnormalities, liver dysfunction, change in blood glucose
BLACK BOX WARNING FOR THROMBOEMBOLISM
contraindicated in pregnancy and breast feeding