Endometrial Pathology

Question 1

When do endometrial polyps occur

Answer 1

Around/after the menopause

Question 2

? cause of Endometrial hyperplasia

Answer 2

Oestrogen

Question 3

Types of Endometrial hyperplasia

Answer 3

Simple, Complex and Atypical

Question 4

Simple EH made up of

Answer 4

Glands and Stroma

Question 5

Complex and Atypical EH both made up of

Answer 5

Crowded, focal glands

Question 6

Atypical Endometrial hyperplasia is a precursor for

Answer 6

Endometrioid carcinoma

Question 7

Precursor for Serous Carcinoma of the Endometrium

Answer 7

Serous intraepithelial carcinoma

Question 8

Type 1 Endometrial Tumours (80%)

Answer 8

Endometrioid and mucinous

Question 9

Type 1 tumours related to

Answer 9

Unopposed oestrogen

Question 10

Type 2 Endometrial Tumours

Answer 10

Serous and clear cell

Question 11

Type 2 patient group

Answer 11

Elderly, post-menopausal women

Question 12

Type 1 genetic mutations

Answer 12

PTEN, KRAS and PIK3CA and ‘micro satellite instability’

Question 13

Lynch syndrome inheritance

Answer 13

AD, MSI

Question 14

Type 2 spread pattern

Answer 14

Fallopian tubes and peritoneal surfaces

Question 15

Endometrioid cancer grading

Answer 15

<5% solid growth = G1, 6-50%=G2, >50%= G3

Question 16

Carcinosarcoma pathology

Answer 16

High grade heterologous elements, with rhabdomyosarcomatous having the worst prognosis

Question 17

Leiomyosarcoma often has

Answer 17

Spindle cell morphology

Question 18

Endometrial stromal sarcomas pathology

Answer 18

Resembles endometrial stroma, presents with DUB and ovarian or lung mets.