Endocrinology CIS Flashcards
What happens to insulin secretion in conditions of hyperglycemia, GI hormones, and beta-adrenergic stimulation?
Increases
What happens to insulin secretion in the presence of catecholamines and somatostatin?
Decreases
Essentials of T1D diagnosis
Polyuria, polydipsia, and weight loss associated with random plasma glucose of 200 mg/dL or more
Plasma glucose of 126 or more after an overnight fast on multiple occasions
Ketonemia, ketonuria, or both
Islet autoantibodies frequently present
Essentials of diagnosis for T2D
Many age 40+ and obese
Polyuria, polydipsia. Ketonuria and weight loss generally uncommon at time of dx. Candidal vaginitis in women may be initial manifestation. Many patients have few or no symptoms
Plasma glucose of 126 or more after overnight fast on multiple occasions. Two hours after 75 g oral glucose, diagnostic values are 200 mg/dL or more
HbA1c 6.5% or more
HTN, dyslipidemia, and atherosclerosis are often associated
Insufficient insulin leads to reduced tissue uptake of glucose. This leads to intracellular _____ and extracellular _____
Hypoglycemia; hyperglycemia
Insufficient insulin leads to reduced tissue uptake of glucose, causing intracellular hypoglycemia. What are the downstream effects of this?
Glucogenesis and gluconeogenesis
Breakdown of fats —> high levels of ketones —> DKA
Decreased protein synthesis —> cachexia, lethargy, polyphagia
Decreased gamma globulins —> susceptibility to infections, impaired wound healing
Insufficient insulin leads to reduced tissue uptake of glucose, causing extracellular hyperglycemia. What are the downstream effects of this?
Hyperosmotic plasma —> dehydration of cells —> hyperglycemic coma
Blood glucose exceeds renal threshold —> glucosuria —> osmotic diureses —> polyuria, polydipsia, hypokalemia, hyponatremia
What is the renal threshold for glucose?
180-200 mg/dL
Effects of insulin on glucose uptake and metabolism:
Insulin binds its receptors —> protein activation cascades —> ______ synthesis —> translocation of ____ transporter to PM and influx of glucose —> _________ —> triglyceride
Glycogen; GLUT4; glycolysis
______ is a facilitative glucose transporter located in the PM of the liver, pancreatic, intestinal, kidney cells as well as in the portal and hypothalamus areas.
GLUT2
GLUT2 has ____ affinity and _____ capacity; transporting dietary sugars, glucose, fructose, and galactose in large range of physiological concentrations, displaying large bidirectional fluxes in and out of cells
Low; high
Insertion of GLUT2 into the ____ membrane of enterocytes induces the acute regulation of intestinal sugar absorption after a meal.
Apical
Is GLUT2 insulin-dependent?
No, GLUT2 protein itself initiates a protein signalling pathway triggering glucose signal from the PM to the transcription machinery
Is GLUT-4 insulin dependent?
Yes; it is responsible for the majority of glucose transport into muscle and adipose cells in anabolic conditions
Describe the process of osmotic diuresis
Increased BG —> increased glomerular filtration of glucose —> increased osmotic pressure of renal tubular fluid —> decreased water reabsorption —> osmotic diuresis