Endocrinology Flashcards
Two types of glands
Endocrine
Exocrine
Type of gland that secretes substances into the blood stream
Endocrine
Type of gland that secretes substances onto a surface usually through a duct
Exocrine
Endocrine or exocrine
Sweat gland
Exocrine
composed of ductless glands that produce hormones which are directly secreted into the bloodstream
Endocrine system
endocrine system is composed of _______ glands that produce hormones which are directly secreted into the _______
Ductless glands
Bloodstream
Endocrine system is a finely tuned system in which the ____, _____, and _____ communicate
Hypothalamus
Pituitary gland
Endocrine glands
Master gland
Hypothalamus
Main function of endocrine system
Regulate bodily function
Maintain homeostasis
Control processes
Endocrine system controls processes such as (4)
Metabolism
Growth
Reproduction
Stress response
Two parts of the pituitary gland
Adenohypophysis
Neurohypophysis
Anterior pituitary gland is also known as
Adenohypophysis
Part of pituitary gland that stores hormones
Neurohypophysis
Hormones released by hypothalamus that goes directly to the posterior pituitary gland
Antidiuretic hormone
Oxytocin
Hypothalamus: GnRH
Adenohypophysis: ____
Target organs: ____
Hypothalamus: Gonadotropin hormone - releasing hormone
Adenohypophysis: Follicle Stimulating Hormone
Luteinizing Hormone
Target organs: Gonads
Hypothalamus:
Adenohypophysis: ACTH
Target organs:
Hypothalamus: Corticotropin Hormone
Adenohypophysis: Adrenocorticotropic Hormone
Target organs: Adrenal cortex
Hypothalamus: PRH
Adenohypophysis: ____
Target organs: ____
Hypothalamus: prolactin releasing hormone
Adenohypophysis: prolactin
Target organs: mammary gland
Hypothalamus: ____
Adenohypophysis: GH
Target organs: ____
Hypothalamus: Growth hormone - releasing hormone
Adenohypophysis: growth hormone
Target organs: liver
Hypothalamus: ADH
Neurohypophysis : ____
Target organs: ____
Hypothalamus: Antidiuretic hormone
Neurohypophysis
Target organs: kidney
Hypothalamus: ____
Neurohypophysis
Target organs: mammary gland
Hypothalamus: oxytocin
Neurohypophysis
Target organs: mammary gland
Physiologic regulatory system involves (2)
Nervous and endocrine system
Difference between nervous and endocrine system in terms of signaling
Nervous - electrical or neural impulse
Endocrine - chemical
nervous system and the endocrine system are closely interrelated and both involved intimately in maintaining _____
Homeostasis
Neuroendocrine system focuses on ____ control to the secretion of pituitary hormones
Hypothalamic control
Neurons release their _____ and ____ at synapses
Neurotransmitter
Neuromodulators
They release their neurotransmitters and neuromodulators at synapses
Neurons
Where do neurons release their neurotransmitter
Synapses
What are the two neurosecretory cells
Hypophyseal cells
Hypophysiotrophic cells
cells that secrete substances directly into the bloodstream to act as hormones
Neurosecretory cells
chemical substances that send a message to another cell in the body.
Hormones
It is derived from a single amino acid
Amines
Example of an amine hormone
Melatonin
hormone derived from tryptophan
Melatonin
Melatonin is derived from what amine
Tryptophan
Example of steroid hormones
FSH
GSH
Types of hormone based on their structure
Amines
Glycoproteins
Steroid
Fatty acid
Peptides
Steroids are lipids derived from _____
Steroids are usually bound to _____
Cholesterol
Protein
lipids derived from cholesterol; usually bound to proteins
Steroids
precursor of catecholamines
Tyrosine
True or false
Hydroxylation of Phe alone will produce catecholamines
False, it can’t
part of the sympathoadrenal axis
Adrenal medulla
initial and rate-limiting step in catecholamine synthesis
conversion of tyrosine to 3,4- dihydroxyphenylalanine
Hormones that are synthesized by rough ER
Peptides and proteins
T or F
All peptide hormones are hydrophilic
True
Fatty acids with 20 carbon atom fatty acid
Eicosanoids
20 carbon atom fatty acid
arachidonic fatty acid
Types of hormone actions
Autocrine
Paracrine
Endocrine
Hormone activity that Act or acts directly on
themselves
Autocrine
Releasing hormones is also known as
hypophyseal hormones
Types of hormones based on functions
Releasing hormone
Inhibitory hormone
Tropic hormone
Effector hormone
Inhibitory hormones is secreted in the ____ and _____
hypothalamus and gastrointestinal tract
This type of hormone suppress the secretion of a particular hormone
Inhibitory hormone
This type of hormone stimulate growth and activity of other endocrine glands
Tropic hormone
What type of hormone is LH based on its function
Tropic hormone
This type of hormone is secreted by endocrine glands but with nonendocrine cells as targets
Effector hormone
What type of hormone is prolactin based on its function
Effector hormone
small region in the brain that plays a crucial role in maintaining homeostasis by regulating various bodily functions through its control over the endocrine system and autonomic nervous system.
Hypothalamus
Hormone which inhibits growth hormone and thyroid stimulating hormone
Somatostatin
This type of hormone inhibits prolactin release
Dopamine
Somatostatin inhibits what
Growth hormone
Thyroid stimulating hormone
processes in the body that regulate hormone secretion. These are basically ways to turn secretion on and off.
Feedback mechanisms or feedback loops
natural process by which a pregnant mammal gives birth, involving the contractions of the uterus to expel the fetus and placenta.
Parturition
This hormone stimulates the uterine muscles to contract during labour
Oxytocin
process in the body that regulates hormone secretion
Feedback mechanism
most common feedback loop
Negative feedback mechanism
Types of negative feedback mechanism
Long
Short
Ultrashort
Type of negative feedback mechanism where
Feedback from hormones produced in the pituitary target glands on the hypothalamus
Long
Type of negative feedback mechanism:
Feedback between the pituitary and hypothalamus
Ultrashort
Pituitary gland is also known as
Hypophysis
Hypophysis is located within the confines of _______
Sella turcica
Hypophysis is connected by the _____ to the ____ of hypothalamus
Infundibular stalk to the median eminence
Weight of pituitary gland
0.6 grams
Pituitary gland measures about ____ mm in transverse and ___ mm in anteroposterior diameter
12
8
Known as the master gland
Pituitary gland
Parts of pituitary gland
Anterior
Intermediate lobe
Posterior
Three types of cells of the anterior pituitary gland
Chromophobe (50%)
Acidophilic (40%)
Basophilic (10%)
T or F
Chromophobe secretes most of the hormone of anterior pituitary gland
False, it does not secrete at all
Cell of adenohypophysis that secretes growth hormone, prolactin, and oxytocin
Acidophilic
precursor of adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), and endorphin (END)
Proopiomelanocortin
body’s natural painkillers
Endorphins
Growth hormone is structurally related to ____ and ____
Prolactin
Human placental lactogen
Growth hormone is classified as what type of hormone based on function
tropic hormone
Growth hormone is also known as
Somatotropin
Low insulin = ___ growth hormone
High
Somatomedin C is also known as
Insulin like growth factor 1 (IgF-1)
Ovarian follicle is produced where
Seminiferous tubules
Used to diagnose premature menopause
FSH
FSH stimulates ___ in males
Sperm production
FSH stimulates ____ in female
Ovarian follicles
stimulates testosterone production in the testes of males
Luteinizing hirmone
It triggers ovulation and progesterone secretion in females.
Luteinizing hormone
What cells produces testosterone
Leydig cells
stimulate the adrenal glands to release cortisol, in response to stress and low blood glucose levels.
Adrenocorticotropic hormone
ACTH is produced by the anterior pituitary gland. Its primary function is to stimulate the adrenal glands to release ______
Cortisol
absence of a menstrual period
Amenorrhea
physiological response that occurs during childbirth, characterized by the release of oxytocin in response to uterine contractions and the stretching of the cervix.
Ferguson reflex
Oxytocin is also known as
Pitocin
Arginine Vasopressin is also known as
Pitressin
maintains osmotic homeostasis by regulating water
balance
Arginine vasopressin
principal regulator of ADH secretion
increased plasma osmolality
potent stimuli to ADH release
Emetic or dehydration
Inhibitor of adh
Ethanol
Cortisol
hyposecretion of GH during growth years
Dwarfism
Major Types of dwarfism
- Proportionate dwarfism
- Disproportionate dwarfism