Endocrinology

Question 1

Most reliable and convenient tests to identify DM in asymptomatic individuals

Answer 1

HbA1C and FPG

Question 2

Atypical DM that is due to pathologic variants in GCK; mild hyperglycemia; HbA1C - oscillates between prediabetes and mild diabetes; usually no micro/macrovascular complication

Answer 2

MODY 2

Question 3

Atypical DM that is due to pathologic variants in hepatocyte nuclear factor 1a; responds with SUs if treated early; (+) microvascular complications

Answer 3

MODY 3

Question 4

Atypical DM that presents with (-) islet Ab; (-) insulin dependency at least 6 months

Answer 4

Latent Auto-immune diabetes

Question 5

All individuals should be tested for Type 2 DM at what age?

Answer 5

All individuals > 45 every 3 years

Question 6

Most potent incretin, stimulates insulin secretion only when the blood glucose is above fasting level

Answer 6

GLP-1

Question 7

An Fc receptor-nonbonding anti-CD monoclonal Ab, delayed onset of stage 3 T1D in HR individuals with multiple Ab and dysglycemia

Answer 7

Teplizumab