Endocrinology Flashcards

1
Q

endocrine

A

glands/cells that release hormones directly into the bloodstream, long distance signalling

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2
Q

exocrine

A

glands that release products through ducts to an external surface/body cavity, localized shorter distances

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3
Q

paracrine

A

cells release chemical messengers that affect nearby cells, short-range no bloodstream transport

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4
Q

lipophilic

A

fat loving molecules (lipid soluble) that can cross cell membranes because they dissolve in fats/lipids

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5
Q

transduction

A

process where cell converts external signal into functional response

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6
Q

signalling cascade

A

sequence of molecular events inside the cell

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7
Q

what distance do hormones communicate over

A

long distances

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8
Q

exocrine examples

A

salivary gland, glands in stomach

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9
Q

endocrine examples

A

thyroid gland, adrenal gland, pituitary gland

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10
Q

endocrine pancreas

A

secretes hormones into the blood to regulate blood glucose

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11
Q

exocrine pancreas

A

secretes digestive enzymes and alkaline fluid into the duodenum

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12
Q

four components of signal transduction

A

receiver: hormone receptor
transducer: receptor response to ligand binding
amplifier: signal transduction pathway increases the number of molecules affected
Responder: something that responds to signal

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13
Q

what is primary intracellular mode of action of water-soluble hormones

A

cell surface receptors activate 2nd messenger system upon hormone binding, 1st messenger carries the signal to cell, 2nd messenger relays the signal inside the cell

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14
Q

enzyme-linked receptors

A

bind hormone, generate second messenger

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15
Q

g protein coupled receptors

A

bind the hormon and activate a G protein

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16
Q

three subunits of g proteins

A

alpha - released when g protein activated
beta, gamma

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17
Q

what is cAMP

A

ATP is converted to it, second messanger that activates protein kinases

18
Q

what would an inhibitory alpha subunit do when released in cAMP sequence

A

shut off sequence of cAMP > protein kinases > phosphorylation of proteins

19
Q

5 main 2nd messenger proteins

A

cAMP, cGMP, DAG, IP3, calcium ions

20
Q

hormone cascade

A

sequence of hormonal activations where one horm. causes release of another, often involves multiple glands and layers of regulation

21
Q

negative feedback

A

maintains homeostasis by reducing hormone secretion once desired effects acheived

22
Q

positive feedback

A

amplifies a hormone response

23
Q

neurosecretory cell

A

type of neuron that produces and releases hormones directly into bloodstream, allows for comm. between nervous and endocrine systems

24
Q

where are neurosecretory cells found

A

hypothalamus, pituary gland

25
Q

pituary gland

A

found at base of brain connected to hypothalamus, master regulator

26
Q

posterior pituitary

A

neural tissue from which hypothalamic neurosecretory cells secrete into the blood

27
Q

anterior pituitary

A

endocrine tissue producing tropic hormones

28
Q

tropic hormone

A

targets other endocrine glands or tissues

29
Q

trophic hormone

A

stimulates growth in target tissues

30
Q

principal neurohormones

A

oxytocin and vasopressin

31
Q

neurohormone process

A
  1. make protein
  2. bring down terminal
  3. bring down to blood
32
Q

four components

A

receiver, transducer, amplifier, responder

33
Q

receiver

A

hormone receptor

34
Q

transducer

A

receptor response to ligand binding

35
Q

amplifier

A

signal transduction pathway increases the number of molecules affected

36
Q

responder

A

responds to the signal

37
Q

feedback loop

A

Low thyroid hormone levels → hypo release TRH
TRH stims ant pit to release TSH
TSH stims thyroid to release thyroid hormones
High thyroid horm level inhibits release of TRH and TSH from hypo and pit

38
Q

primary sex characteristics

A

male/female sex organ traits (size, function, etc.)

39
Q

secondary sex characteristics

A

benefits mating processes (behaviour, flashiness, etc.)

40
Q

hypophysio hormones

A

stim/inhib secretion of peptide hormoens from anterior pituitary gland

41
Q
A