Endocrinology Flashcards
endocrine
glands/cells that release hormones directly into the bloodstream, long distance signalling
exocrine
glands that release products through ducts to an external surface/body cavity, localized shorter distances
paracrine
cells release chemical messengers that affect nearby cells, short-range no bloodstream transport
lipophilic
fat loving molecules (lipid soluble) that can cross cell membranes because they dissolve in fats/lipids
transduction
process where cell converts external signal into functional response
signalling cascade
sequence of molecular events inside the cell
what distance do hormones communicate over
long distances
exocrine examples
salivary gland, glands in stomach
endocrine examples
thyroid gland, adrenal gland, pituitary gland
endocrine pancreas
secretes hormones into the blood to regulate blood glucose
exocrine pancreas
secretes digestive enzymes and alkaline fluid into the duodenum
four components of signal transduction
receiver: hormone receptor
transducer: receptor response to ligand binding
amplifier: signal transduction pathway increases the number of molecules affected
Responder: something that responds to signal
what is primary intracellular mode of action of water-soluble hormones
cell surface receptors activate 2nd messenger system upon hormone binding, 1st messenger carries the signal to cell, 2nd messenger relays the signal inside the cell
enzyme-linked receptors
bind hormone, generate second messenger
g protein coupled receptors
bind the hormon and activate a G protein
three subunits of g proteins
alpha - released when g protein activated
beta, gamma