Endocrinology

Question 1

Phaechromocytoma - 10% rule

Answer 1

10% malignant
10% outside adrenals
10% familial
10% bilateral

Question 2

Familial phaeochromocytoma

what 3 syndromes are they associated with?

Answer 2

neurofibromatosis

multi endocrine neoplasia

von Hippel-Lindau

Question 3

MEN-1

Answer 3

parathyroid hyperplasia (95%) –> hyperPTH
pituitary (70%)
pancreas (50%, e.g. Insulinoma, gastrinoma)
also: adrenal and thyroid

Question 4

Zollinger-Ellison

Answer 4

PC: abdo pain + diarrhoea + malabsorption

excessive gastrin –> multiple gastroduodenal ulcers
usually from gastrinoma in duodenum or pancreas

diagnose with fasting gastrin or secretin stimulation test

manage with high-dose PPIs

1/3 have MEN-1