Endocrine System Chapter 13 Flashcards

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1
Q

Endocrine

A

Includes cells, tissues, and organs (collectively called endocrine glands) secretes hormones which act on target cells

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2
Q

Local hormones

A

Paracrine hormone

Autocrine hormone

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3
Q

Paracrine hormone

A

Released into interstitial for local action

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4
Q

Autocrine hormone

A

affect only the secreting cell (or self)

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5
Q

Hormone

A

a biochemical secreted by a cell to affect the function of other cells (or itself) by means of contact or blood transport to these target cells with specific receptors of proteins or glycoprotiens

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6
Q

Functions of hormones

A

Regulate metabolic processes
control rates of some chemical reactions
Aid in transport through membranes
Regulate water balance, electrolyte balance, BP, reproduction and growth

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7
Q

Types of hormones

A

Steroid and nonsteroidal

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8
Q

Steroid

A

Synthesized from cholesterol. Soluble in lipids, diffuse into cells to activate genes on DNA to synthesize specific proteins or can inhibit genes

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9
Q

Prostaglandins

A

Produced in a wide variety of cells; regulate neighboring cells (paracrine secretions)

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10
Q

Actions of hormones

A

Alter metabolic processes

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11
Q

Nonsteroid

A

a hormone that is the first messenger. binds to specific receptor molecule complex on the membrane. This causes its activity site to chemically alter the membrane transport mechanisms.

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12
Q

Control

A

three different systems but all employ negative feedback. Hormones have half live.

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13
Q

Three control systems

A

Hormonal
Nervous
Vascular

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14
Q

Hormonal

A

Hypothalamus->ant pituitary: releases tropic (influencing) hormones stimulating other endocrine glands to release

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15
Q

Nervous

A

nervous system-> some endocrine glands directly

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16
Q

Vascular

A

plasma levels-> some endocrine glands directly

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17
Q

Pituitary

A

At the base of the brain, attached to the hypothalamus via infundibulum. Lies in the sella turcica

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18
Q

Anterior chemical hormonal

A

the hypothalamus secretes releasing hormones which are carried to the pituitary via the hypophyseal portal veins

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19
Q

5 types of secretory cells in the pituitary

A
Growth (GH)
Prolactin (PRL)
Thyroid stimulating (TSH)
Adrenocorticotropic (ACTH)
Follicle Stimulating (FSH)
Luteinizing (LH)
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20
Q

Growth hormone

A

(somatotropin) stimulates cells to enlarge and rapidly divide, enhances protein synthesis and amino acid transfer through cell membranes. Released if protein deficiency or loooooooooow glucose

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21
Q

Prolactin (PRL)

A

milk production

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22
Q

Thyroid stimulating (TSH)

A

Excess levels lead to goiter

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23
Q

Adrenocorticotropic (ACTH)

A

Acts on adrenal cortex

24
Q

Follicle stimulating (FSH)

A

Growth and development of follicles to secrete estrogen and mature eggs/sperm production

25
Q

Luteinizing (LH)

A

Promotes secretion of sex hormones

26
Q

Posterior (pituitary)

A

production via neurosecretory cells,, control via hypothalamus electrically

27
Q

Antidiuretic (ADH)

A

Decrease urine urine formation and cause vasoconstriction because there are two different receptors on target cells

28
Q

Oxytocin (OT)

A

Smooth muscle contraction, mild antidiuretic

29
Q

Thryoid

A

removes iodine from the blood for producing (T3 and T4) which regulate the metabolism of CHO, proteins and fats

30
Q

Thyroxine (T4)

A

regulates BMR, 95%

31
Q

Triiodothyronine (T3)

A

Regulates BMR, 5X stronger

32
Q

Calcitonin

A

Lowers blood calcium levels by inhibiting osteoclasts and stimulating osteoblasts and increasing kidney excretion

33
Q

Graves

A

Autoimmune disease
Antibodies bind to TSH receptors, gets stimulated = overactive thyroid. 24/7 will produce thyroid hormones making a goiter

34
Q

Hyperthyroidism

A

BMR is up
Can’t sit down
Low weight
Will have a goiter

35
Q

Infantile

A
under active infant
metabolism slows down
creatinism
stunted growth
Mental retardation
Sluggish
Irreversible
36
Q

Parathyroid (PTH)

A

increase blood calcium levels by stimulating osteoclasts and inhibiting osteoblasts and decreasing kidney excretion

37
Q

Adrenal

A

medulla: sympathetically wired

38
Q

Epiephrine

A

(Adrenalin) Fight/Flight, increased HR, BP, breathing,

39
Q

Nonepiephrine

A

(nonadrenalin) fight/flight

40
Q

Aldosterone

A

water retention by conserving sodium ions

41
Q

Renin-Angiotensin system

A

if BP drops, the kidney releases renin which decomposes angiotensinogen releasing angiotensin I. stimulates the release of aldosterone

42
Q

ACE inhibitors

A

treats hypertension by blocking formation of angiotensin II.

43
Q

Cortisol

A

stimulates glucose synthesis from non carbs (gluconeogenesis)

44
Q

Androgens

A

supplement gonads some are converted into estrogens

45
Q

Cushings

A

comes from ACTH over stimulated adrenal cortex
elevated blood glucose
increase NA retention

46
Q

Pancreas

A

contains both exocrine gland tissue and endocrine tissue. Endocrine portion consists of 3 kinds of secreting cells that make up the pancreatic islets

47
Q

2 kinds of secreting cells in the pancreas

A

Glucagon

Insulin

48
Q

Glucagon

A
  1. ) Glycogen into glucose
  2. ) Converts nonCHO into glucose
  3. ) Catabolize fats (breaks down to get more energy)
49
Q

Insulin

A
  1. ) Glucose into glycogen (decrease sugar levels)
  2. ) inhibits nonCHO into glucose
  3. ) Facilitate diffuision of glucose into cells
  4. ) Amino Acids into cells
  5. ) Increases protein synthesis
  6. ) Adipose synthesis and storage of fat
50
Q

Hyperglacemia

A

blood sugars increased

51
Q

Protein synthesis

A

blood sugars decrease

52
Q

Fat synthesis

A

blood sugars decrease, drops

53
Q

Type 1 diabetes

A

Juvenile, beta cells are wiped out

54
Q

Type 2 diabetes

A

40 and older
overweight progressively loose insulin receptors
(under exercise, over eating, hereditary)

55
Q

Pineal

A

melatonin, nerve impulses from optic nerve eventually reach pineal gland causing a decrease in production. Part of the regulation of circarian rhythms

56
Q

Thymus

A

behind sternum. Thymosins: wbc production and differentiation

57
Q

Reproductive Glands

A

ovaries and testes